Effects of exercise-induced arterial hypoxaemia on limb muscle fatigue and performance

Clinical and Experimental Pharmacology & Physiology
Lee M Romer, Jerome A Dempsey

Abstract

1. Reductions in arterial O(2) saturation (-5% to -10%S(a)o(2) below rest) occur over time during sustained heavy-intensity exercise in a normoxic environment, caused primarily by the effects of acid pH and increased temperature on the position of the HbO(2) dissociation curve. 2. We prevented the desaturation incurred during exercise at approximately 90% VO(2 MAX) via increased fraction of inspired O(2) (F(i)o(2)) (0.23 to 0.29) and showed that exercise time to exhaustion was increased. 3. We used supramaximal magnetic stimulation (1-100 Hz) of the femoral nerve to test for quadriceps fatigue. We used mildly hyperoxic inspirates (F(i)o(2) 0.23 to 0.29) to prevent O(2) desaturation. We then compared the amount of quadriceps fatigue incurred following cycling exercise at S(a)o(2) 91% vs 98% with each trial carried out at identical work rates and for equal durations. 4. Preventing the normal exercise-induced O(2) desaturation prevented about one-half the amount of exercise-induced quadriceps fatigue; plasma lactate and effort perception were also reduced. In a subset of less fit subjects who showed only minimal arterial hypoxaemia during sustained exercise (S(a)o(2) approximately 95%), breathing a mildly hypoxic inspirate (F(i)o(...Continue Reading

References

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Citations

May 11, 2011·European Journal of Applied Physiology·J DekerleH Carter
Sep 29, 2011·European Journal of Applied Physiology·Antonios KyparosIoannis S Vrabas
Oct 20, 2012·European Journal of Applied Physiology·Jodii WhitePeter Peeling
Sep 3, 2010·Scandinavian Journal of Medicine & Science in Sports·N DecorteS Verges
Aug 6, 2021·Respiratory Physiology & Neurobiology·Carl J AdeDavid C Poole

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