Effects of exercise intensity compared to albuterol in individuals with cystic fibrosis

Respiratory Medicine
Courtney M WheatleyEric M Snyder

Abstract

Although exercise is a vital component of the therapy prescribed to individuals with cystic fibrosis (CF), it is not a priority due to a finite amount of treatment time and the view that exercise is not as beneficial as pharmacological treatments by many individuals with CF. We sought to compare the therapeutic benefits of exercise and their prescribed bronchodilator albuterol. CF (n = 14) and healthy (n = 16) subjects completed three visits, a baseline screening with VO2 max test and two treatment visits. On the two treatment visits, subjects completed spirometry and diffusing capacity of the lungs for nitric oxide (DLNO) maneuvers either at baseline, 60, and 110 min post-albuterol administration, or at baseline and the midway point of three separate 15 min exercise bouts at low, moderate and vigorous intensity (25, 50 and 65% of the maximum workload, respectively). With moderate exercise the increase in DLNO was double (39 ± 8 vs 15  ± 6% change) and the level of bronchodilation similar (23% change) when compared to 110 min post-albuterol in individuals with CF. During exercise FVC became reduced (-309 ± 66 mL with moderate exercise) and the increase in FEV1 was attenuated (103 ± 39 vs 236 ± 58 mL, exercise vs. albuterol) whe...Continue Reading

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Citations

Sep 7, 2017·High Altitude Medicine & Biology·Courtney M WheatleyBruce D Johnson
Mar 25, 2019·Expert Review of Respiratory Medicine·Nathan WardAnne E Holland
Nov 2, 2017·The Cochrane Database of Systematic Reviews·Thomas RadtkeSusi Kriemler
Apr 9, 2019·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Alexander L BischEric M Snyder
Sep 22, 2015·Current Opinion in Pulmonary Medicine·Helge HebestreitThomas Radtke
Apr 2, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Evgenia I KalamaraGuergana Petrova

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