Effects of Exercise on Chemotherapy Completion and Hospitalization Rates: The OptiTrain Breast Cancer Trial

The Oncologist
S MijwelHelene Rundqvist

Abstract

Exercise during chemotherapy is suggested to provide clinical benefits, including improved chemotherapy completion. Despite this, few randomized controlled exercise trials have reported on such clinical endpoints. From the OptiTrain trial we previously showed positive effects on physiological and health-related outcomes after 16 weeks of supervised exercise in patients with breast cancer undergoing chemotherapy. Here, we examined the effects of exercise on rates of chemotherapy completion and hospitalization, as well as on blood cell concentrations during chemotherapy. Two hundred forty women scheduled for chemotherapy were randomized to 16 weeks of resistance and high-intensity interval training (RT-HIIT), moderate-intensity aerobic and high-intensity interval training (AT-HIIT), or usual care (UC). Outcomes included chemotherapy completion, hospitalization, hemoglobin, lymphocyte, thrombocyte, and neutrophil concentrations during chemotherapy. No significant between-groups differences were found in the proportion of participants who required dose reductions (RT-HIIT vs. UC: odds ratio [OR], 1.08; AT-HIIT vs. UC: OR, 1.39), or average relative dose intensity of chemotherapy between groups (RT-HIIT vs. UC: effect size [ES], 0.0...Continue Reading

Associated Clinical Trials

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Citations

May 26, 2020·British Journal of Pharmacology·Tim SchauerJesper Frank Christensen
Nov 3, 2020·Frontiers in Nutrition·Yitong Xu, Connie J Rogers
Jan 1, 2021·Cancers·Miguel A OrtegaMiguel A Álvarez-Mon
Jul 4, 2021·Journal for Immunotherapy of Cancer·Michael P GustafsonRichard J Simpson
Nov 16, 2021·Frontiers in Immunology·David B BartlettClaudio L Battaglini

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Clinical Trials Mentioned

NCT02522260

Software Mentioned

OptiTrain

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