Effects of exercise on gait and motor imagery in people with Parkinson disease and freezing of gait

Parkinsonism & Related Disorders
Peter S MyersGammon M Earhart

Abstract

Exercise improves gait in Parkinson disease (PD), but whether exercise differentially affects people with PD with (freezers) and without freezing of gait (non-freezers) remains unclear. This study examines exercise's effects on gait performance, neural correlates related to these effects, and potential neural activation differences between freezers and non-freezers during motor imagery (MI) of gait. Thirty-seven participants from a larger exercise intervention completed behavioral assessments and functional magnetic resonance imaging (fMRI) scans before and after a 12-week exercise intervention. Gait performance was characterized using gait velocity and stride length, and a region of interest (ROI) fMRI analysis examined task-based blood oxygen-level dependent (BOLD) signal changes of the somatomotor network (SMN) during MI of forward (IMG-FWD) and backward (IMG-BWD) gait. Velocity (F(1,34) = 55.04, p < 0.001) and stride length (F(1,34) = 77.58, p < 0.001) were significantly lower for backward versus forward walking in all participants. The ROI analysis showed freezers had lower BOLD signal compared to non-freezers in the cerebellum (F(1,32) = 7.01, p = 0.01), primary motor (left: F(1,32) = 7.09, p = 0.01; right: F(1,32) = 7.45...Continue Reading

Citations

Jun 20, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Carla Silva-BatistaCarlos Ugrinowitsch
Apr 7, 2020·Neurorehabilitation and Neural Repair·Laurie A KingFay B Horak
Feb 20, 2020·Movement Disorders Clinical Practice·Femke HulzingaPieter Ginis
Jul 21, 2020·Neurorehabilitation and Neural Repair·Amgad DrobyAnat Mirelman
May 14, 2020·European Journal of Physical and Rehabilitation Medicine·Manon RoyYoshimasa J Sagawa
Jan 26, 2020·Life Sciences·Ya-Shuo FengFeng Zhang
Feb 6, 2021·Brain Sciences·Amit AbrahamGammon M Earhart
Jan 19, 2021·Neural Plasticity·Giulia BommaritoElisa Pelosin
Dec 5, 2019·NeuroImage. Clinical·Komal BhartiPatrizia Pantano
Mar 14, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Wenjing SongGuiyun Cui

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