Effects of exercise on urinary excretion of albumin and beta 2-microglobulin in young patients with mild essential hypertension without treatment and during long-term propranolol treatment

Scandinavian Journal of Clinical and Laboratory Investigation
E B PedersenJ S Larsen

Abstract

The effect of exercise on the urinary excretion of albumin, beta 2-microglobulin, renal plasma flow (RPF) and glomerular filtration rate (GFR) was studied in two groups of young patients with mild essential hypertension, one comprising nine untreated patients (1) and one comprising eight patients treated with propranolol (2), and in a group comprising ten normotensive healthy control subjects (3). The urinary excretion of albumin and beta 2-microglobulin, RPF and GFR were measured during four consecutive periods: a control period of 40 min; two exercise periods of 20 min each, with a load of 75 W and 100 W, respectively; and a control period. During exercise group 1 showed an increase in albumin excretion and a decrease in beta 2-microglobulin excretion, while group 2 showed an increase in albumin excretion during heavy exercise only and unchanged beta 2-microglobulin excretion, and group 3 showed unchanged albumin and beta 2-microglobulin excretion. RPF and GFR were reduced during exercise in all groups, most markedly in the hypertensive groups. During both exercise loads albumin excretion was higher and RPF was lower in group 1 than in 3. In group 2 albumin excretion was lower than in 1 during the light exercise load, whereas...Continue Reading

References

Jun 1, 1976·Journal of Applied Physiology·H GalboJ Hilsted
Dec 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·P E EvrinI Berggård
Sep 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
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Jan 1, 1968·The Journal of Clinical Investigation·P O KohlerW D Odell

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Citations

Nov 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·E Vittinghus, C E Mogensen
Dec 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J NarvarteG Ramirez
Jan 1, 1996·European Journal of Clinical Pharmacology·C RangemarkO Samuelsson
Sep 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·A ChachatiP J Lefèbvre
Jan 1, 1991·Critical Reviews in Toxicology·A Bernard, R R Lauwerys
Jul 1, 1994·The Journal of International Medical Research·B N Panayiotou
Feb 1, 1987·Kidney International·C E Mogensen
May 1, 1982·Kidney International·E Vittinghus, C E Mogensen

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