Effects of exercise training and detraining on oxidized low-density lipoprotein-potentiated platelet function in men

Archives of Physical Medicine and Rehabilitation
Jong-Shyan Wang, Shu-Er Chow

Abstract

To investigate how exercise training and detraining affect oxidized low-density lipoprotein (Ox-LDL)-potentiated platelet function in men. Cohort study. Department of physical medicine and rehabilitation. Ten sedentary men (mean age +/- standard error of the mean, 21.6+/-0.2 y) who did not engage in any regular physical activity for at least 1 year before the study. Subjects cycled on an ergometer at about 50% of maximal oxygen consumption for 30 minutes daily, 5 days a week, for 8 weeks, then detrained for 12 weeks. During the experimental period, blood samples from the subjects were collected before and immediately after a progressive exercise test (ie, strenuous, acute exercise) every 4 weeks. The following measurements were taken when the subjects were at rest and immediately after exercise: plasma lipid profile, plasma Ox-LDL level, and platelet aggregation and intracellular calcium concentration ([Ca2+]i) elevation induced by adenosine disphosphate (ADP) alone or simultaneous ADP and Ox-LDL addition. Analytical results indicated that: (1) plasma total cholesterol and LDL levels were reduced after exercise training from 151+/-7 mg/dL and 58+/-2 mg/dL to 133+/-6 mg/dL and 46+/-2 mg/dL (P<.05), respectively, whereas the plas...Continue Reading

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Citations

Aug 26, 2006·Journal of Biomedical Science·Jong-Shyan Wang
Apr 30, 2016·Cell Biochemistry and Biophysics·Henrique Andrade R FonsecaMaria Cristina O Izar
Nov 12, 2015·BioMed Research International·Stefan Heber, Ivo Volf
Feb 26, 2016·Medicine and Science in Sports and Exercise·Stefan HeberIvo Volf
Mar 13, 2018·Clinical Hemorheology and Microcirculation·Mahmoudreza TaghizadehMahmood Naderi

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