Effects of exercise training and supplementation with selenium nanoparticle on T-helper 1 and 2 and cytokine levels in tumor tissue of mice bearing the 4 T1 mammary carcinoma

Nutrition
Mahdieh Molanouri ShamsiFabricio Azevedo Voltarelli

Abstract

Physical exercise decreases the incidence of breast cancer and also improves survival in breast cancer patients. However, the mechanistic basis of these protective effects of exercise is not well known. Changes in tumor cytokines, such as oncostatin-M (OSM), have been associated with modulation of antitumor immune responses in breast cancer. Exercise and antioxidants such as selenium affect both antitumor immune responses as well as tumor cytokine expression. Thus, the aim of this study was to determine the effects of aerobic exercise training (AET) and selenium nanoparticle (SeNP) administration on T-helper 1 and 2 and tumor tissue cytokines in mice bearing the 4 T1 mammary carcinoma. We examined the effects of 6 wk of AET and SeNP administration (100 μg three times/wk) on tumor size, concentration of tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-4 and OSM in tumor tissue and INF-γ and IL-4 in splenocytes of 64 mice bearing the 4 T1 mammary carcinoma. AET increased OSM levels in tumor tissue. Moreover, AET increased levels of TNF-α in tumor tissue, whereas SeNP supplementation decreased IL-4 levels tumor tissue. Also, the combination of AET and SeNP administration decreased tumor volume and increase...Continue Reading

Citations

Dec 27, 2018·International Journal of Molecular Sciences·Heng Wee TanYan-Ming Xu
Dec 12, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Helene Nissrine Daou
Nov 3, 2020·Frontiers in Nutrition·Yitong Xu, Connie J Rogers
Feb 13, 2021·Antioxidants·Carmen Griñan-LisonSergio Granados-Principal
Jan 25, 2020·Medicine and Science in Sports and Exercise·Zeynab NezamdoostAnna Keska
Mar 14, 2020·Medicine and Science in Sports and Exercise·Zhi XiaNelo Eidy Zanchi
Apr 4, 2021·Sports·Polyxeni SpiliopoulouGerasimos Terzis
Jun 15, 2021·Advanced Healthcare Materials·Cláudio FerroHélder A Santos

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