Effects of exercise training on carotid intima-media thickness in patients with type 2 diabetes and coronary artery disease. Influence of carotid plaques

Cardiovascular Diabetology
Rune ByrkjelandSvein Solheim

Abstract

Carotid intima-media thickness (cIMT) holds prognostic information for future cardiovascular disease and is associated with the extent of coronary atherosclerosis. We investigated the effect of exercise on cIMT progression in patients with both type 2 diabetes and coronary artery disease (CAD). Patients with type 2 diabetes and CAD (n = 137) were randomized to exercise training or standard follow-up. The 12 month exercise program contained 150 min weekly of combined aerobic and resistance training. High-resolution ultrasonography of the distal part of the common carotid artery (CCA) was performed to measure cIMT before and after the intervention. The CCA and the carotid bulb were scanned for the presence of atherosclerotic plaques. Differences in changes between the randomized groups were calculated by one-way ANCOVA. In the total population no difference in changes of cIMT from baseline to 12 months was observed between the exercise group and controls [-0.016 mm (95 % CI -0.037 to 0.006) vs. -0.007 mm (95 % CI -0.029 to 0.015), p = 0.57]. However, there was a significant interaction between the effect of exercise training and the presence of carotid plaques (p = 0.013), and significant reduced cIMT was demonstrated in the exer...Continue Reading

References

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Citations

Jan 24, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Rune ByrkjelandSvein Solheim
Jan 24, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Vibeke BratsethIngebjørg Seljeflot
Jan 23, 2020·International Journal of Environmental Research and Public Health·Lars-Kristian LundeMarit Skogstad
Jun 6, 2020·International Journal of Environmental Research and Public Health·Asgeir MamenMarit Skogstad
Jul 24, 2020·Expert Review of Cardiovascular Therapy·Chueh-Lung HwangShane A Phillips
May 12, 2016·Current Diabetes Reports·Fida Bacha, Samuel S Gidding
May 4, 2018·Cardiovascular Diabetology·Shanhu QiuUwe Schumann
Mar 18, 2021·Metabolic Syndrome and Related Disorders·Do Kyung KimWon Hah Park
Nov 7, 2021·The Cochrane Database of Systematic Reviews·Grace DibbenRod S Taylor

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT01232608

Software Mentioned

Osirix MD

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