PMID: 6109226Dec 1, 1980Paper

Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas

Metabolism: Clinical and Experimental
R N HoneyG C Weir

Abstract

The effects of exogenous insulin were examined in the isolated perfused chicken pancreas with the duodenum excluded. At low background glucose (50 mg/dl), exogenous insulin infused at a concentration of 20,000 microU/ml elicited clear stimulation of somatostatin secretion while simultaneously inhibiting glucagon release. When the background glucose concentration was elevated to 750 mg/dl, exogenous insulin, had no effect on either somatostatin or glucagon release. When graded doses of exogenous insulin were infused into the chicken pancreas at low background glucose, low concentrations (200 microU/ml) had little effect on somatostatin or glucagon release, but higher concentrations (2000 and 20,000 microU/ml) had clear effects on both somatostatin and glucagon secretion. Glucagon infused at 100 ng/ml stimulated both insulin and somatostatin release. When somatostatin was infused at 25 ng/ml, clear inhibition of glucagon was seen with insulin inhibited to a lesser extent. This study supports the notion of a negative feedback relation between B and D-cells of the pancreatic islets and suggests a paracrine mediation.

Citations

May 19, 2018·Nature Reviews. Endocrinology·Patrik Rorsman, Mark O Huising
Feb 19, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sean M Hartig, Aaron R Cox
Jun 18, 1998·Annals of the New York Academy of Sciences·N Rideau
Jan 27, 2021·Biology·Rui GaoQuan Zhang
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A Grossman
Jan 1, 1990·Comparative Biochemistry and Physiology. A, Comparative Physiology·N RideauJ Simon

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