Effects of exogenous lactate administration on fat metabolism and glycogen synthesis factors in rats

Physical Activity and Nutrition
Sunghwan KyunKiwon Lim

Abstract

Lactate has several beneficial roles as an energy resource and in metabolism. However, studies on the effects of oral administration of lactate on fat metabolism and glycogen synthesis are limited. Therefore, the purpose of the present study was to investigate how oral administration of lactate affects fat metabolism and glycogen synthesis factors at specific times (0, 30, 60, 120 min) after intake. Male Sprague Dawley (SD) rats (n = 24) were divided into four groups as follows: the control group (0 min) was sacrificed immediately after oral lactate administration; the test groups were administered lactate (2 g/kg) and sacrificed after 30, 60, and 120 min. Skeletal muscle and liver mRNA expression of GLUT4, FAT/CD36, PDH, CS, PC and GYS2 was assessed using reverse transcription-polymerase chain reaction. GLUT4 and FAT/CD36 expression was significantly increased in skeletal muscle 120 min after lactate administration. PDH expression in skeletal muscle was altered at 30 and 120 min after lactate consumption, but was not significantly different compared to the control. CS, PC and GYS2 expression in liver was increased 60 min after lactate administration. Our results indicate that exogenous lactate administration increases GLUT4 an...Continue Reading

References

Nov 28, 1988·The American Journal of Medicine·F Q NuttallA W Tan
Jun 1, 1986·Medicine and Science in Sports and Exercise·G A Brooks
Jun 1, 1987·Journal of Applied Physiology·R W StevensonR T Frizzell
Sep 1, 1981·Clinical Science·J R SuttonC J Toews
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·M G Hollidge-HorvatG J Heigenhauser
May 7, 2002·Exercise and Sport Sciences Reviews·Lawrence L Spriet, George J F Heigenhauser
Jun 28, 2002·The Journal of Biological Chemistry·Oliver E OwenRichard W Hanson
Jan 18, 2003·Journal of Applied Physiology·Parco M SiuStephen E Alway
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A RobergsDaryl Parker
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Amira Klip
Aug 27, 2009·Scandinavian Journal of Medicine & Science in Sports·L LeickH Pilegaard
Oct 7, 2009·The Journal of Physiology·George A Brooks
May 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·Jason L TalanianLawrence L Spriet
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew E MerrittShawn C Burgess
Jul 23, 2014·Journal of the International Society of Sports Nutrition·Jisu KimKiwon Lim
May 25, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Yu KitaokaHideo Hatta
Jul 29, 2016·Journal of Nutritional Science and Vitaminology·Jisu KimKiwon Lim
Feb 6, 2017·Journal of Exercise Nutrition & Biochemistry·Jisu Kim, Kiwon Lim
Apr 5, 2018·Cell Metabolism·George A Brooks
May 23, 2018·Molecular Therapy : the Journal of the American Society of Gene Therapy·Natalie PursellChengjung Lai

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Citations

Oct 30, 2020·International Journal of Environmental Research and Public Health·Sunghwan KyunKiwon Lim

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