Effects of exposure to 0.06 ppm ozone on FEV1 in humans: a secondary analysis of existing data.

Environmental Health Perspectives
James S BrownWilliam F McDonnell

Abstract

Ozone is a potent photochemical oxidant that produces transient, reversible decrements in the lung function of acutely exposed individuals. A recent study provided previously unavailable clinical data for 30 healthy young adults exposed to O(3) at 0.06 ppm. That study showed significant effects of 0.08 ppm on lung function, confirming the findings of others. However, exposure to 0.06 ppm O(3) was not reported to significantly affect lung function. We conducted this analysis to reevaluate the existing lung function data of the volunteers previously exposed to 0.06 ppm O(3). We obtained pre- and postexposure data on forced expiratory volume in 1 sec (FEV(1)) for all subjects who were previously exposed for 6.6 hr to filtered air or to 0.06 ppm or 0.08 ppm O(3). We used standard statistical methods appropriate for paired comparisons to reanalyze FEV(1) responses after exposure to 0.06 ppm O(3) relative to filtered air. Controlling for filtered air responses, 24 of the 30 subjects experienced an O(3)-induced decrement in FEV(1). On average, 0.06 ppm O(3) exposure caused a 2.85% reduction in FEV(1) (p < 0.002), which was consistent with the predicted FEV(1) response from existing models. Although the average response was small, two ...Continue Reading

References

May 1, 1991·Archives of Environmental Health·W F McDonnellD H Horstman
Apr 1, 1987·Journal of Applied Physiology·M J Hazucha
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May 15, 2007·Inhalation Toxicology·William F McDonnellMarjo V Smith
Oct 15, 1996·Environmental Toxicology and Pharmacology·W F McDonnell

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Citations

Oct 22, 2011·Archives of Environmental & Occupational Health·Gordana PehnecMladen Pavlović
Nov 18, 2009·Chemical Research in Toxicology·Kelly M Wynalda, Robert C Murphy
Mar 13, 2009·The New England Journal of Medicine·Michael JerrettMichael Thun
Oct 23, 2012·Environmental Health Perspectives·Lauren ZeiseKathryn Z Guyton
Jul 24, 2015·American Journal of Respiratory Cell and Molecular Biology·Chee Bing OngJack R Harkema
Jul 10, 2013·Journal of Applied Toxicology : JAT·Julie E GoodmanSonja N Sax
Aug 26, 2010·Inhalation Toxicology·Allen S LefohnWilliam C Adams
Oct 5, 2013·Critical Reviews in Toxicology·Julie E GoodmanLorenz R Rhomberg
Dec 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lindsay Wichers StanekDaniel L Costa
Jul 28, 2009·American Journal of Respiratory and Critical Care Medicine·James S Brown
May 19, 2009·American Journal of Respiratory and Critical Care Medicine·Edward S SchelegleRoblee P Allen
Jan 10, 2018·Journal of the Air & Waste Management Association·Annette C Rohr
Jan 13, 2017·The European Respiratory Journal·George D ThurstonBert Brunekreef
Jan 11, 2011·American Journal of Respiratory and Critical Care Medicine·Chong S KimDavid Diaz-Sanchez
Oct 5, 2017·Annals of the American Thoracic Society·John R Balmes
Jan 7, 2019·Ecotoxicology and Environmental Safety·Muhammad Abdul Basit Ahmad TajudinMazrura Sahani
May 28, 2021·Ecotoxicology and Environmental Safety·Wan-Mei SongHuai-Chen Li

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Software Mentioned

Graph Pad Prism
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