PMID: 6979533Apr 1, 1982Paper

Effects of exposure to acid on alveolar epithelial water and solute transport

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
K J Kim, E D Crandall

Abstract

Water and solute transport properties of normal and acid-exposed bullfrog alveolar epithelium were determined under controlled conditions. Paired lungs from the same animal were studied in Ussing chambers. Tissue bioelectric parameters, permeabilities of water and solutes, and hydraulic conductivity were measured. Results from control lungs were compared with those observed after the alveolar epithelium was exposed to acid (pH 2.0-4.0) for variable periods of time (1-60 min). Acid exposure appears to initially damage tissue active transport mechanisms, causing a marked fall in potential difference at pH less than or equal to 3.0. Increases in tissue conductance and permeability to solutes occurred after a variable time lag. Water permeability did not change after acid exposure. Equivalent homogeneous pore radius increased as time of exposure to acid increased. It is concluded that the bullfrog alveolar epithelium, normally resistant to water and solute flux, loses its ability to transport ions actively and gradually becomes leaky after exposure to acid (pH less than or equal to 3.0). The pathway for movement of water across alveolar epithelium may be different from that for solutes.

Citations

Jan 1, 1997·Journal of Applied Physiology·J Widdicombe
Nov 16, 2002·Journal of Applied Physiology·Yves BerthiaumeMichael A Matthay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
E D Crandall, K J Kim
The American Review of Respiratory Disease
E D Crandall
Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
K J Kim, E D Crandall
© 2021 Meta ULC. All rights reserved