Effects of exposure to BPF on development and sexual differentiation during early life stages of zebrafish (Danio rerio)

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Qian YangShubao Shen

Abstract

Bisphenol F (BPF) has become a predominant bisphenol contaminant in recent years. It has significant estrogenic properties in both in vivo and in vitro studies. We have previously studied the disrupting mechanisms of BPF on the hypothalamic-pituitary-gonadal axis of adult zebrafish. However, the effects of BPF exposure on development and sexual differentiation of zebrafish embryos/larvae remain unclear. To determine the effects of BPF on the critical stage of sex differentiation in zebrafish, zebrafish embryos/larvae were exposed to 1, 10, 100, and 1000 μg/L BPF from fertilization to 60 days post-fertilization (dpf). Developmental malformations were induced by exposure to BPF from 2 h post-fertilization (hpf), with a LC50 of 10,030 μg/L at 96 hpf and 9391 μg/L at 120 hpf. Long-term exposure during sex differentiation tended to result in a female sex ratio bias. Histological analyses at 60 dpf indicated that the development of ovo-testes and immature ovaries was induced by 100 and 1000 μg/L BPF. Homogenate testosterone levels decreased and 17β-estradiol levels increased in zebrafish in a concentration-dependent manner. BPF exposure suppressed gene expression of double sex, Mab3-related transcription factor 1(dmrt1), fushi tarazu...Continue Reading

Citations

Dec 28, 2019·International Journal of Environmental Research and Public Health·Jong-Joo KimVijay Kumar
Oct 4, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anna MentorAnna Mattsson
Feb 10, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Felix BurkhardtOlga Polydorou
Jul 13, 2019·Ecotoxicology and Environmental Safety·Clei Endrigo PiazzaAfonso Celso Dias Bainy
Apr 2, 2021·Water Environment Research : a Research Publication of the Water Environment Federation·Giacomo RussoLucia Grumetto

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