Effects of exposure to Di-(2-ethylhexyl) phthalate (DEHP) during lactation and puberty on sexual maturation and glycemic homeostasis in males rats

Clinical Nutrition ESPEN
Amanda Caroline VenturelliAnderson Joel Martino Andrade

Abstract

This study aimed to evaluate the effects of Di-(2-ethylhexyl) phthalate (DEHP) exposure during lactation or puberty on the glycemic homeostasis and the sexual maturation of male rats. Thus, in a first experiment, Wistar rats were exposed to DEHP (7.5 mg/kg/day and 75 mg/kg/day) from the 1st to the 21st day of lactation. The dams and their male offspring were evaluated regarding weight gain, food ingestion, serum concentrations of glucose and lipids, and insulin tolerance test (ITT). In addition, the male offspring was submitted to the quantification of insulin secretion in pancreatic islets isolated in vitro, concentration of fecal androgen metabolites and determination of the age of prepucial separation. In a second round of experiments, peripuberal male rats were exposed to the same DEHP doses for 30 days (22nd to 52nd day of life). These animals were evaluated regarding weight gain and food ingestion, concentration of fecal androgen metabolites, and prepucial separation along the treatment period. The ITT and analysis of serum concentrations of glucose and lipids were carried out at the end of the treatment. The male offspring presented higher vulnerability to DEHP exposure, revealing changes in the glycemic homeostasis in a...Continue Reading

Citations

Jan 26, 2020·International Journal of Environmental Research and Public Health·Katarina BaralićDanijela Đukić-Ćosić
Dec 20, 2017·Environmental Science and Pollution Research International·Asma BeltifaHedi Ben Mansour

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.