PMID: 15329471Aug 27, 2004Paper

Effects of exposure to genistein during pubertal development on the reproductive system of male mice

The Journal of Reproduction and Development
Beom-Jun LeeSang-Yoon Nam

Abstract

Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of the male reproductive system. Twenty-one days old ICR mice weaned from dams fed with a casein-based AIN-76A diet during gestation and lactation were exposed to genistein (2.5 and 5.0 mg/kg/day, p.o.) for 5 weeks. 17beta-Estradiol (7.5 microg/kg/day) and corn oil were used for the positive and negative vehicle controls, respectively. The animals were fed the casein-based AIN-76A diet throughout the experiment. There were no significant differences in body weights of mice between the genistein groups and the negative control group. No significant differences in relative reproductive organ weights were found among all experimental groups. Sperm counts in epididymis and testes were slightly decreased in the genistein-exposed groups compared with control group. Sperm motile characteristics in genistein-exposed groups were slightly higher than those of the control group. Levels of phospholipid hydroxide glutathione peroxidase mRNA in the testis, epididymis, and prostate of mice exposed to genistein or estradiol were significantly higher than those of the co...Continue Reading

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Citations

Feb 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Claudia MontaniDiego Di Lorenzo
Mar 25, 2005·Anatomy and Embryology·In-Jeoung BaekSang-Yoon Nam
Feb 8, 2008·Experimental Animals·Sunhee ShinYun-bae Kim
Feb 23, 2010·Molecular and Cellular Endocrinology·Christopher R CederrothSerge Nef
Nov 19, 2009·International Journal of Andrology·Christopher R CederrothSerge Nef
Sep 24, 2010·Journal of Biomedicine & Biotechnology·K SvechnikovO Söder
Mar 4, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Ana C MoreiraVilma A Sardão
May 13, 2017·Pharmaceutical Biology·Rong TangYing-Jie Hu
Dec 23, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Karl K RozmanDavid Umbach

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