PMID: 13575779Sep 20, 1958Paper

Effects of external currents on duration and amplitude of normal and prolonged action potentials from single nodes of Ranvier

The Journal of General Physiology
P MUELLER

Abstract

Duration and amplitude of normal and prolonged action potentials from single nodes of Ranvier vary as functions of potential changes induced by currents from an external source. The quantitative relations between externally applied potential and the resulting potential generated within the system are analyzed in order to obtain information about the kinetics of the electromotance,-potential,-and chemical changes taking place during excitation. The following preliminary conclusions are drawn: A depolarizing and a repolarizing process (positive and negative electromotance) increase and decrease with the potential. For a sudden potential displacement the negative electromotance reaches its new value at a faster rate than the positive electromotance. Since the individual values of the two electromotances depend on the potential and since they both generate a potential which is proportional to the difference of their absolute values, the values of either electromotance are determined by this difference as well as by any externally induced potential change.

References

Jan 20, 1955·The Journal of General Physiology·M ALTAMIRANOH GRUNDFEST
Sep 20, 1958·The Journal of General Physiology·P MUELLER

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Citations

Jan 1, 1960·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J J CHANG, R F SCHMIDT
Feb 29, 1964·Nature·S EHRENPREIS
Apr 1, 1959·Proceedings of the National Academy of Sciences of the United States of America·R L Nó, G A Condouris
Aug 1, 1960·Journal of Cellular and Comparative Physiology·J J CHANG

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