PMID: 6410084Aug 1, 1983Paper

Effects of external radiation therapy for cancer of the prostate on the serum concentrations of testosterone, follicle-stimulating hormone, luteinizing hormone and prolactin

The Journal of Urology
R TomićP O Löfroth

Abstract

Testosterone, luteinizing hormone, follicle-stimulating hormone and prolactin were analyzed in serum from 31 patients with carcinoma of the prostate treated primarily with megavoltage radiation therapy. The total tumor dose varied between 58 and 71 gray (mean 63.5 gray). Absorbed doses to the testes were measured at approximately 1 to more than 10 gray. We investigated retrospectively 17 patients 3 to 60 months (mean 20 months) after therapy and found significantly lower serum testosterone concentrations and significantly higher luteinizing and follicle-stimulating hormone concentrations than in age-matched controls. Of the patients 14 were followed before and after radiation treatment. Testosterone concentrations were reduced significantly 1 week as well as 3 months after treatment but pre-treatment values were found on analysis 6 and 12 months after treatment. The values for luteinizing and follicle-stimulating hormones were significantly higher 3, 6 and 12 months after radiation treatment compared to pre-treatment values. The follicle-stimulating hormone value already increased after 1 week. The greatest observed testosterone alteration occurred 1 week after treatment in patients who received more than 10 gray over the gonad...Continue Reading

Citations

Jun 9, 1999·British Journal of Cancer·J T HartmannC Bokemeyer
Sep 14, 2012·International Journal of Impotence Research·A W PastuszakM Khera
Dec 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P G Cornes, M Shahidi
Mar 30, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ramadoss SivakumarKarundevi Balasubramanian
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Feb 12, 2019·Journal of Cellular Physiology·Bagher FarhoodAmirhossein Sahebkar
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Jan 30, 2020·Anti-cancer Agents in Medicinal Chemistry·Keywan MortezaeeAmirhossein Sahebkar
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