Effects of extracellular calcium and magnesium on central respiratory control in the brainstem-spinal cord of neonatal rat

Brain Research
Shun-ichi KuwanaT Natsui

Abstract

The influence of extracellular Ca2+ and Mg2+ concentrations ([Ca2+]ECF and [Mg2+]ECF, respectively) on central respiratory control was analyzed using the isolated brainstem-spinal cord of the neonatal rat. Central respiratory activity was recorded from the C4 ventral roots. The depth profile of [Ca2+]ECF below the ventral medullary surface was measured with ion-sensitive electrodes. The gradient in [Ca2+]ECF disappeared about 1 h after changing superfusate Ca2+ ([Ca2+]CSF) from 2 to 0.5 mM, but not even in 2 h after switching to Ca2+-free superfusate. High [Ca2+]CSF (4 mM) or high [Mg2+]CSF (4, 8 mM) decreased respiratory frequency (fR), whereas low [Ca2+]CSF (0.5 mM) increased fR and augmented the respiratory CO2 responsiveness. High [Ca2+]CSF as well as low [Mg2+]CSF (0.5 mM) disturbed respiratory rhythm and pattern, which were markedly restored by high CO2. The depressing effect of high [Ca2+]ECF and the stimulating effect of low [Ca2+]ECF on the medullary neuronal activity were confirmed by perforated patch recordings. These results suggest that [Ca2+]ECF and [Mg2+]ECF determine the excitability of the respiratory neuron network by modulating the neuronal surface potential, transmembrane Ca2+ influx, Ca2+-sensitive cation c...Continue Reading

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Citations

Jun 24, 2014·Respiratory Physiology & Neurobiology·Takeo SugitaShun-ichi Kuwana
May 2, 2009·Respiratory Physiology & Neurobiology·Klaus Ballanyi, Araya Ruangkittisakul
Feb 21, 2006·The European Journal of Neuroscience·Shun-ichi KuwanaKunihiko Obata
Jun 12, 2010·Annals of the New York Academy of Sciences·Kristine C CowleyBrian J Schmidt
Sep 14, 2010·Respiratory Physiology & Neurobiology·Araya RuangkittisakulKlaus Ballanyi
Jul 30, 2004·Anesthesia and Analgesia·Masanori KashiwagiJunzo Takeda
Nov 5, 2004·American Journal of Physiology. Cell Physiology·Robert W PutnamNicola A Ritucci
Jul 24, 2008·Anesthesiology·Junya KuribayashiShun-Ichi Kuwana
Jul 23, 2002·Journal of Applied Physiology·Yasumasa OkadaFrederic L Eldridge
Jul 7, 2021·Respiratory Physiology & Neurobiology·Shino KatsukiMasahiko Izumizaki

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