Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture

Acta Biomaterialia
Lili WuBérengère J C Luthringer

Abstract

Coculture of osteoblasts and osteoclasts is a subject of interest in the understanding of how magnesium (Mg)-based implants influence the bone metabolism and remodeling upon degradation. Human telomerase reverse transcriptase (hTERT) transduced mesenchymal stem cells (SCP-1) were first differentiated into osteoblasts with osteogenic supplements and then further cocultured with peripheral blood mononucleated cells (PBMC) without the addition of osteoclastogenesis promoting factors. Concomitantly, the cultures were exposed to variable Mg extract dilutions (0, 30×, 10×, 5×, 3×, 2× and 1×). Phenotype characterization documented that while 2× dilution of Mg extract was extremely toxic to osteoclast monoculture, monocytes in coculture with osteoblasts exhibited a greater tolerance to higher Mg extract concentration. The dense growth of osteoblasts in cultures with 1× dilution of Mg extract suggested that high concentration of Mg extract promoted osteoblast proliferation/differentiation behavior. The results of intracellular alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) activities as well as protein and gene expressions of receptor activator of nuclear factor kappa-B ligand (RANKL), macrophage colony-stimul...Continue Reading

References

Sep 1, 1972·Experimental Cell Research·M Takeichi, T S Okada
Feb 1, 1997·Journal of Cellular Biochemistry·N JaiswalS P Bruder
Jul 31, 1999·Experimental Hematology·G D Roodman
Nov 28, 2001·Drug Discovery Today·Eva GrimaudDominique Heymann
Feb 15, 2002·European Journal of Nutrition·D A Bushinsky
Jul 19, 2002·Journal of Biomedical Materials Research·Y YamasakiN Matsuura
Sep 5, 2002·Journal of Biomedical Materials Research·H ZreiqatM Shakibaei
Oct 24, 2002·European Journal of Nutrition·Fraņoise I BussièreYves Rayssiguier
May 16, 2003·Nature·William J BoyleDavid L Lacey
Mar 30, 2004·Biomaterials·Arndt F SchillingMichael Amling
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nunziata MorabitoNicola Frisina
Aug 27, 2005·Biomaterials·Frank WitteHenning Windhagen
Oct 26, 2005·Biomaterials·Mark P StaigerGeorge Dias
Nov 14, 2006·Bone·Masataka Asagiri, Hiroshi Takayanagi
Mar 29, 2007·Journal of Biomedical Materials Research. Part a·F WitteE Willbold
Mar 29, 2007·Journal of Biomedical Materials Research. Part a·F WitteE Willbold
Apr 5, 2007·Annals of the New York Academy of Sciences·Joana Barbosa MeloCatarina Resende Oliveira
Jun 6, 2007·Journal of Biomedical Materials Research. Part a·Liping XuKe Yang
Nov 7, 2008·Journal of Materials Science. Materials in Medicine·Marcia S SaderGloria A Soares
May 12, 2009·Acta Biomaterialia·Carla LorenzSannakaisa Virtanen
Jun 24, 2009·Acta Biomaterialia·Shaoxiang ZhangYujun Bian
May 26, 2010·Clinical Oral Implants Research·Jin-Woo ParkHwangjun Song
May 27, 2010·The Journal of Biological Chemistry·Liza J Raggatt, Nicola C Partridge
Mar 16, 2011·Journal of Cell Science·Julie C CrockettMiep H Helfrich
Jun 19, 2012·Trends in Endocrinology and Metabolism : TEM·Tomoki NakashimaHiroshi Takayanagi

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Citations

Apr 5, 2016·Acta Biomaterialia·Katharina JähnEric Hesse
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Abbas Fazel Anvari-YazdiMaryam Sadat Mohtasebi
Sep 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eunkuk ParkSeon-Yong Jeong
Dec 2, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yunfei DingYuncang Li
Mar 24, 2018·Journal of Biomedical Materials Research. Part a·Kun YuYong Zhu
Jun 7, 2019·Tissue Engineering. Part C, Methods·Agathe GrémareDamien Le Nihouannen
May 12, 2018·International Journal of Molecular Sciences·Azzurra SargentiStefano Iotti
Jan 20, 2019·International Journal of Molecular Sciences·Fabiana MammoliChiara Frassineti
May 29, 2018·Innovative Surgical Sciences·Nicole Gabriele GrünAnnelie-Martina Weinberg
Dec 13, 2019·Biomedical Engineering Online·Su WangYongqiang Hao
Jul 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Felix HanßkeHans G Börner
May 1, 2020·Metallomics : Integrated Biometal Science·M OmidiB J C Luthringer-Feyerabend
Oct 1, 2020·International Journal of Molecular Sciences·Fabiana da Silva Lima, Ricardo Ambrósio Fock
Dec 30, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anique D Ter BraakeJoost G J Hoenderop
Dec 24, 2019·Kidney International·Anique D Ter BraakeJeroen H F de Baaij
Dec 15, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·M V Pendón-Ruiz de MierM Rodríguez
Jan 23, 2021·International Journal of Molecular Sciences·Andreea-Mariana NegrescuAnisoara Cimpean
Nov 7, 2020·Scientific Reports·Catarina C CoelhoSusana R Sousa
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Sachiko HiromotoKotaro Doi
May 16, 2018·Biomaterials·Chuying MaJian Yang
Dec 16, 2020·ACS Biomaterials Science & Engineering·Rita GelliFrancesca Ridi

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