Effects of extracellular potassium diffusion on electrically coupled neuron networks

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Xing-Xing Wu, Jianwei Shuai

Abstract

Potassium accumulation and diffusion during neuronal epileptiform activity have been observed experimentally, and potassium lateral diffusion has been suggested to play an important role in nonsynaptic neuron networks. We adopt a hippocampal CA1 pyramidal neuron network in a zero-calcium condition to better understand the influence of extracellular potassium dynamics on the stimulus-induced activity. The potassium concentration in the interstitial space for each neuron is regulated by potassium currents, Na(+)-K(+) pumps, glial buffering, and ion diffusion. In addition to potassium diffusion, nearby neurons are also coupled through gap junctions. Our results reveal that the latency of the first spike responding to stimulus monotonically decreases with increasing gap-junction conductance but is insensitive to potassium diffusive coupling. The duration of network oscillations shows a bell-like shape with increasing potassium diffusive coupling at weak gap-junction coupling. For modest electrical coupling, there is an optimal K(+) diffusion strength, at which the flow of potassium ions among the network neurons appropriately modulates interstitial potassium concentrations in a degree that provides the most favorable environment fo...Continue Reading

References

Aug 10, 1990·Science·C J McBainR Dingledine
Apr 1, 1985·Journal of Neurophysiology·G G SomjenJ O McNamara
Mar 1, 1994·Epilepsy Research·W R AndersonA A Maki
May 29, 2000·Biophysical Journal·K C Chen, C Nicholson
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y LoewensteinH Sompolinsky
Mar 1, 2003·Biophysical Journal·Jianwei ShuaiDominique M Durand
Feb 28, 1956·The Journal of Physiology·B FRANKENHAEUSER, A L HODGKIN
Apr 2, 2004·Journal of Neurophysiology·M BazhenovT J Sejnowski
Aug 9, 2005·Journal of Theoretical Biology·Eun-Hyoung Park, Dominique M Durand
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Flavio Fröhlich, Maxim Bazhenov
Apr 5, 2007·Physical Biology·Suhita Nadkarni, Peter Jung
May 16, 2007·Physical Review Letters·Thomas Nowotny, Mikhail I Rabinovich
Oct 18, 2007·Brain Cell Biology·Audrey MercerAlex M Thomson
Apr 29, 2008·Biophysical Journal·Eun-Hyoung ParkDominique M Durand
Feb 3, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Antonio Zaza
Mar 17, 2010·Physical Biology·Troy LauMichal Zochowski
Jul 7, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dominique M DurandAlicia L Jensen
Nov 10, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·E I EkinciG Jerums
Mar 8, 2011·Physical Biology·Fang Wei, Jianwei Shuai
Feb 9, 2012·Journal of Computational Neuroscience·Daniela BianchiMichele Migliore
Jun 2, 2012·Journal of Biological Physics·Ernest Barreto, John R Cressman
Jul 10, 2012·Brain Research·Audrey Mercer
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Xing-Xing Wu, J W Shuai

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