Effects of extracts of high- and low-chromium brewer's yeast on metabolism of glucose by hepatocytes from rats fed on high- or low-Cr diets

The British Journal of Nutrition
E S Holdsworth, E Neville

Abstract

Brewer's yeast was grown on a defined medium containing glucose, ammonia, salts and vitamins plus tracer 51Cr without (low-Cr) or with (high-Cr) carrier Cr. The two batches of yeast differed by more than 100-fold in Cr content, containing 80 ng and 10 micrograms Cr/g dry yeast respectively. Extraction and fractionation procedures were designed to isolate Cr complexes with properties similar to those reported for glucose tolerance factor. After weaning, rats were reared on rat cubes (normal diet) or on a diet containing less than 0.1 microgram Cr/kg (low-Cr diet), or on the low-Cr diet supplemented with Cr (1 mg Cr/kg). Hepatocytes from these rats were incubated with [U-14C]glucose and incorporation of 14C into glycogen was measured. Incorporation of glucose-C into glycogen was enhanced by some yeast fractions in the presence of insulin, but had less effect in the absence of insulin. No difference could be detected between the responses to fractions from high- or low-Cr yeast extracts, or between responses by hepatocytes from animals fed on normal or low-Cr diets with or without Cr supplementation. Glycogen synthetase (EC 2.4.1.11) activity (total and percentage in the a form) was similar in hepatocytes isolated from animals on ...Continue Reading

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Citations

Mar 1, 1991·The British Journal of Nutrition·E S HoldsworthE Neville
Jan 23, 2009·Biological Trace Element Research·Nicholas R RhodesJohn B Vincent
Jun 30, 2000·BioFactors·D M Stearns
Jan 17, 2013·Journal of Agricultural and Food Chemistry·Lu LiuHankie Uluko
Jan 12, 2019·Archives of Physiology and Biochemistry·Günter A Müller
Apr 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·John B Vincent
Jul 15, 2000·Acta Microbiologica Et Immunologica Hungarica·P RasporM Skrt
Jan 1, 1992·Nutrition Research Reviews·J H Beattie, A Avenell
Sep 15, 2012·Chemistry & Biodiversity·John B Vincent, Sharifa T Love
May 1, 1997·The Journal of Nutrition·P G Reeves
Jan 31, 2016·Experimental Biology and Medicine·Nitsa MirskyAhuva Dovrat
Aug 25, 1999·Metabolism: Clinical and Experimental·J S StrifflerR A Anderson

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