Effects of extremely low frequency pulsed magnetic fields on diabetic nephropathy in streptozotocin-treated rats

Biomedical Engineering Online
Feijiang LiGuanghao Shen

Abstract

Extremely low frequency pulsed magnetic fields (ELFPMF) have been shown to induce Faraday currents and measurable effects on biological systems. A kind of very high frequency electromagnetic field was reported that it improved the symptoms of diabetic nephropathy (DN) which is a major complication of diabetes. However, few studies have examined the effects of ELFPMF DN at the present. The present study was designed to investigate the effects of ELFPMF on DN in streptozotocin (STZ)-induced type 1 diabetic rats. Adult male SD rats were randomly divided into three weight-matched groups: Control (non-diabetic rats without DN), DN + ELFPMF (diabetic rats with DN exposed to ELFPMF, 8 h/days, 6 weeks) and DN (diabetic rats with DN exposed to sham ELFPMF). Renal morphology was examined by light and electron microscopy, vascular endothelial growth factor (VEGF)-A and connective tissue growth factor (CTGF) were measured by enzyme linked immune sorbent assay. After 6 weeks' ELFPMF exposure, alterations of hyperglycemia and weight loss in STZ-treated rats with DN were not found, while both positive and negative effects of ELFPMF on the development of DN in diabetic rats were observed. The positive one was that ELFPMF exposure attenuated th...Continue Reading

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Citations

Mar 19, 2019·Electromagnetic Biology and Medicine·Yue LiWeidong Pan
Jun 10, 2020·Molecular Biology Reports·Abbas KarimiMasoumeh Valipour
Mar 18, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mingming ZhaiChunxu Hai
Oct 8, 2020·Cell Metabolism·Calvin S CarterVal C Sheffield

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Methods Mentioned

BETA
ELISA
transmission electron microscopy
biopsies

Software Mentioned

SPSS
ELFPMF

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