Effects of fasting and 3,3',4,4',5,5'-hexabromobiphenyl on plasma transport of thyroxine and retinol: fasting reverses elevation of retinol

Journal of Toxicology and Environmental Health
P A SpearH Garcin

Abstract

Male Wistar rats were injected ip with 0 or 20 mg/kg 3,3',4,4',5,5'-hexabromobiphenyl and blood samples were collected 1, 3, 6, 7, and 8 d later. At 8 d after the injection, serum retinol was increased 30% and serum thyroxine was decreased 26% relative to control values. These effects were apparently unrelated to transthyretin in that the biphenyl did not alter the proportion of thyroxine binding in vitro to the prealbumin fraction of serum proteins. Separate groups of control and HBBP-injected rats did not receive food on d 7 (i.e., 24-h fast) and d 8 after injection (i.e., 48-h fast). Fasting decreased the serum retinol and thyroxine concentrations as well as the proportion of thyroxine binding in vitro to the prealbumin fraction of serum. The decreases in retinol and thyroxine concentrations associated with fasting are therefore ascribed to a decrease in the concentration of transthyretin in circulation.

References

Feb 1, 1979·The Journal of Endocrinology·P Higueret, H Garcin
Jan 1, 1978·Toxicology and Applied Pharmacology·E E McConnellD W Dalgard
Aug 18, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y IngenbleekM De Visscher
Sep 1, 1988·Canadian Journal of Physiology and Pharmacology·P A SpearJ F Narbonne
Dec 1, 1987·Environmental Research·K MuraiM Fujishima
Jan 1, 1974·Vitamins and Hormones·P A PetersonA Vahlquist
Nov 1, 1971·The Journal of Clinical Investigation·F R Smith, D S Goodman
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Related Concepts

3,3',4,4',5,5'-hexabromobiphenyl
High Pressure Liquid Chromatography Procedure
SDS-PAGE
Fasting
Injections, Intraperitoneal
Polybrominated Biphenyls
Prealbumin
Novothyral
Thyroxine-Binding Proteins
Aquasol A

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