Effects of fasting and refeeding on jejunal morphology and cellular activity in rats in relation to depletion of body stores

Scandinavian Journal of Gastroenterology
Caroline HaboldJ-H Lignot

Abstract

Intestinal mucosa atrophy following a period of starvation characterized by the mobilization of fat stores for energy expenditure (phase II) worsen after a long fast marked by an increase in protein catabolism (phase III). However, the morphology of the jejunum is completely restored after 3 days of refeeding. The aim of this study was to determine the mechanisms involved in the rapid jejunal restoration following the critical phase III. Jejunal structure was observed through conventional and environmental scanning electron microscopy, whilst cellular dynamics were studied using classical optic microscopy tools and immunohistochemistry. Mucosal structural atrophy during fasting proved to worsen over the two phases. During phase II, apoptosis is still present at the tip of the villi, the number of mitosis in crypts showed a 30% decrease and a transient drop in cell migration is observed. During phase III, however, an 85% rise in mitosis was noticed along with an increase in cell migration and the disappearance of apoptotic cells at the villus tips. This increased cell renewal continues after food ingestion. Starved rats appeared to be in a phase of energy sparing in phase II, with depressed cellular events in the intestinal muco...Continue Reading

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Citations

Nov 25, 2005·Pflügers Archiv : European journal of physiology·Caroline HaboldJean-Hervé Lignot
May 1, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·L P van MinnenL M A Akkermans
Jul 8, 2011·The British Journal of Nutrition·Aya MoriyaKatsumi Shibata
Feb 8, 2006·Annual Review of Physiology·Tobias WangDavid J Randall
Oct 11, 2007·BMC Genomics·Milka SokolovićWouter H Lamers
Nov 8, 2008·BMC Genomics·Milka SokolovićWouter H Lamers
Dec 5, 2009·World Journal of Gastroenterology : WJG·Zhong-Hui LiuDe-Chang Diao
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Jul 8, 2010·The Journal of Surgical Research·Juquan SongMarc G Jeschke
Jun 23, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jiro OmataKazuo Hase
Nov 3, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Tiziano VerriAlessandro Romano
Jul 20, 2007·Pflügers Archiv : European journal of physiology·Caroline HaboldJean-Hervé Lignot
Sep 25, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Marshall D McCueDavid K Meyerholz
Jan 8, 2020·PloS One·Emma T HelmNicholas K Gabler
Jan 29, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Ling-Qing ZengYao-Guang Zhang
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Mar 18, 2008·The Journal of Experimental Biology·Christian L Cox, Stephen M Secor

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