Effects of fasting, intermittent feeding, or continuous parenteral nutrition on rat liver and brain energy metabolism as assessed by 31P-NMR

Physiology & Behavior
G BodokyN Szeverenyi

Abstract

We wanted to determine what happens to brain PCr and ATP relative to that in liver during a series of dietary manipulation consisting of a severe fast, during eating (when nutrients are intermittently supplied), and during and after PN-100, when an excess amount of nutrients are continuously supplied, using 31P-NMR spectroscopy, in rats randomized to a Fast or Fed group in which energy was provided either as chow or as PN-100. Liver ATP concentration, and brain and liver 31P-nuclear magnetic resonance (NMR) spectras were measured serially. Brain energy metabolism was not different between groups and among days. In contrast, Fasted group showed increased liver ATP/Pi ratio and decreased ATP concentration and ATP/phosphomonoester ratio, there being no difference between Fed and PN-100 groups. Data suggest that brain energy metabolism is maintained regardless of whether energy is supplied intermittently or continuously, and during a negative caloric intake period, brain energy metabolism is quantitatively preserved, suggesting that ATP production by liver is subservient to brain ATP state.

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Citations

Jan 1, 1996·Neuroscience and Biobehavioral Reviews·E I OparaW G Hammond
Jul 14, 2005·Annual Review of Nutrition·Mark P Mattson
Nov 3, 2010·Nutrition·Stephen CunnaneStanley I Rapoport
Jun 19, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Georg Hennemann, Eric P Krenning
Nov 17, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Achim Peters
Dec 29, 2020·International Journal of Food Sciences and Nutrition·Walter CurrentiFabio Galvano
Feb 27, 2021·Frontiers in Neuroscience·Marie SprengellAchim Peters

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