Effects of Fasting on 18 F-DCFPyL Uptake in Prostate Cancer Lesions and Tissues with Known High Physiologic Uptake

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Maurits WondergemRemco J J Knol

Abstract

In the literature, a 4- to 6-h fast is recommended before a patient undergoes PET/CT with 2-(3-(1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL); however, a scientific underpinning for this recommendation is lacking. Therefore, we performed a study to determine the impact of fasting on 18F-DCFPyL uptake. Methods: The study included 50 patients who fasted at least 6 h before 18F-DCFPyL administration and 50 patients who did not. Activity (SUVmax) was measured in lesions characteristic of prostate cancer and in normal tissues known to express high physiologic uptake. Results: Uptake in suspected lesions did not differ between the cohorts. 18F-DCFPyL uptake in the submandibular gland, liver, and spleen was significantly higher in the fasting than the nonfasting cohort. Conclusion: Our data show that fasting does not significantly affect 18F-DCFPyL uptake in suspected malignant lesions but does result in significantly lower 18F-DCFPyL uptake in tissues with high physiologic uptake. The absolute differences in uptake were relatively small; therefore, the effects of fasting on the diagnostic performance can be considered negligible.

References

Jun 3, 2000·Human Pathology·L BubendorfM J Mihatsch
Jan 21, 2006·AJR. American Journal of Roentgenology·Osama MawlawiMarvin Chasen
Apr 22, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Zsolt SzaboMartin G Pomper
Mar 15, 2016·Clinical Nuclear Medicine·Christina BluemelKen Herrmann
Dec 10, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Xin LiMartin G Pomper
Mar 12, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Wolfgang P FendlerKen Herrmann
Apr 15, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Clemens KratochwilAlfred Morgenstern
Apr 30, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Maurits WondergemIgle J de Jong

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Citations

Dec 14, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Rudolf A WernerRalph A Bundschuh
May 23, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Karine SahakyanSteven P Rowe
Apr 14, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Etienne RousseauFrançois Bénard
Jul 22, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Felix DietleinMarkus Dietlein
Dec 7, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Janet H PollardJohn J Sunderland

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