Effects of fasting on neuroendocrine function and follicle development in lean women

The Journal of Clinical Endocrinology and Metabolism
R AlveroB R Olson

Abstract

A 72-h fast in normal weight women during the follicular phase results in transient alterations in neuroendocrine function, but follicle development and follicular phase length remain unaltered. In this study we evaluated neuroendocrine and ovulatory function in lean women (body fat, < or = 20%) undergoing a similar 72-h fast. Compared to fed controls, fasted lean women experienced significant weight loss, blunting of the diurnal variation of cortisol, suppression of the nocturnal TSH rise, and a decrease in T3 levels after a 72-h fast. In contrast to similarly fasted, normal weight women, lean women have significantly higher evening cortisol levels and do not exhibit a normal nocturnal TSH rise after the fast. Lean fasted women exhibited a 19% decrease in the number of LH pulses over 24 h compared to fed women (12.9 +/- 1.3 vs. 16.0 +/- 1.9; P < 0.05). Fasting did not result in significant differences in mean LH, LH amplitude, LH area under the curve, and mean FSH levels in these lean women. Of the seven fasted cycles, two were anovulatory. In the five women studied in fed and fasted cycles, one had interrupted lead follicle development with anovulation, and four had significant lengthening of the follicular phase compared to ...Continue Reading

Citations

Oct 6, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M N HarvieA Howell
May 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean L ChanChristos S Mantzoros
Sep 16, 2011·The Journal of Clinical Endocrinology and Metabolism·Vasiliki A MoragianniChristos S Mantzoros
Jan 24, 2007·Fertility and Sterility·Annemarie A van ElburgBart C J M Fauser

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