Effects of fasting on oxidative stress in rat liver mitochondria

Free Radical Research
M SorensenG Barja

Abstract

While moderate caloric restriction has beneficial effects on animal health state, fasting may be harmful. The present investigation was designed to test how fasting affects oxidative stress, and to find out whether the effects are opposite to those previously found in caloric restriction studies. We have focused on one of the main determinants of aging rate: the rate of mitochondrial free radical generation. Different parameters related to lipid and protein oxidative damage were also analyzed. Liver mitochondria from rats subjected to 72 h of fasting leaked more electrons per unit of O(2) consumed at complex III, than mitochondria from ad libitum fed rats. This increased leak led to a higher free radical generation under state 3 respiration using succinate as substrate. Regarding lipids, fasting altered fatty acid composition of hepatic membranes, increasing the double bond and the peroxidizability indexes. In accordance with this, we observed that hepatic membranes from the fasted animals were more sensitive to lipid peroxidation. Hepatic protein oxidative damage was also increased in fasted rats. Thus, the levels of oxidative modifications, produced either indirectly by reactive carbonyl compounds (N(epsilon)-malondialdehyde-...Continue Reading

References

May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Jan 1, 1989·Free Radical Research Communications·M CrescimannoN D'Alessandro
Jan 1, 1974·Journal of Biochemistry·N TateishiY Sakamoto
Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Jan 1, 1995·The Japanese Journal of Physiology·Y NagashimaA Kuroshima
Jul 1, 1994·The American Journal of Physiology·J A NorthG R Buettner
Jul 5, 1996·Science·R S Sohal, R Weindruch
Jan 1, 1996·Free Radical Biology & Medicine·B P Yu
Nov 5, 1997·Archives of Biochemistry and Biophysics·C LeeuwenburghJ W Heinecke
Sep 7, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T A ZainalR Weindruch
Nov 15, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M J ForsterR S Sohal
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R GredillaG Barja
Aug 13, 2002·Journal of Bioenergetics and Biomembranes·Gustavo Barja
Jul 1, 1956·Journal of Gerontology·D HARMAN
Oct 17, 2003·The Journal of Biological Chemistry·Kathy PfeifferHermann Schägger
Jan 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lisa BevilacquaMary-Ellen Harper
Feb 6, 2004·Physiological Genomics·Matthias BauerJoerg D Katzenberger
Jun 12, 2004·Biological Reviews of the Cambridge Philosophical Society·Gustavo Barja
Nov 3, 2004·Biochimica Et Biophysica Acta·Hildur Palsdottir, Carola Hunte
Dec 29, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jon J RamseyKevork Hagopian

❮ Previous
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Citations

Feb 14, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·José Pablo Vázquez-MedinaRudy M Ortiz
Feb 12, 2013·BMC Genomics·Alinne Batista AmbrosioOdalys G Cabrera
May 20, 2006·Lipids in Health and Disease·Lisa B MahoneyThomas N Seyfried
Jun 29, 2010·The Journal of Experimental Biology·José Pablo Vázquez-MedinaRudy M Ortiz
Mar 25, 2011·The Journal of Experimental Biology·José Pablo Vázquez-MedinaRudy M Ortiz
Apr 13, 2012·The Journal of Experimental Biology·José Guadalupe Soñanez-OrganisRudy M Ortiz
Nov 14, 2013·Archives of Medical Research·Peter Stenvinkel, Richard J Johnson
Sep 8, 2011·Physiological and Biochemical Zoology : PBZ·Jason C L Brown, James F Staples
Jun 19, 2012·Physiological and Biochemical Zoology : PBZ·Geiger SylvieFrancois Criscuolo
Oct 11, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Segal M BoazDaniel E Crocker
May 21, 2011·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Michael S TiftDaniel E Crocker
Jun 23, 2009·Free Radical Biology & Medicine·Mohamed A AbdelmegeedByoung-Joon Song
May 19, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sherif AwadDileep N Lobo
Mar 1, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Daniel E CrockerCory D Champagne
Feb 13, 2007·Trends in Plant Science·Graham NoctorChristine H Foyer
Oct 2, 2007·Proteomics·Björn KuhlaCornelia C Metges
Feb 10, 2009·Journal of Food Science·R X SantosP I Moreira
Jun 13, 2014·Proteomics·Thierry WasselinFabrice Bertile
Dec 27, 2011·Redox Report : Communications in Free Radical Research·Alicia J Kowaltowski
Mar 29, 2014·Fundamental & Clinical Pharmacology·Amie J Dirks-NaylorRaean Mabolo
Jul 4, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Marcelo Hermes-LimaElida G Campos
Jul 23, 2013·Analytical Biochemistry·L S TessuttiA A Alves
Apr 7, 2017·Proceedings. Biological Sciences·Nicky RollingsChristopher R Friesen
Nov 2, 2016·The Journal of Experimental Biology·Quentin SchullJean-Patrice Robin
May 11, 2016·Molecular and Cellular Biology·Min Sung JooSang Geon Kim
Dec 6, 2006·Pflügers Archiv : European journal of physiology·Elena Thomàs-MoyàAna María Proenza
Jan 27, 2019·The Journal of Experimental Biology·Damien RousselYann Voituron
Oct 14, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason C L BrownJames F Staples
Oct 12, 2007·Physiological Reviews·A J HulbertW A Buttemer
Sep 16, 2018·Scientific Reports·P DongilC Sanz
Apr 8, 2020·Frontiers in Physiology·Xiaofang GengCunshuan Xu
Oct 20, 2018·Functional Ecology·Karine SalinNeil B Metcalfe
Jan 16, 2021·Free Radical Biology & Medicine·Filippo Scialo, Alberto Sanz
Nov 22, 2020·General and Comparative Endocrinology·Samir Khal De SouzaRoselis Silveira Martins Da Silva
Nov 19, 2020·Antioxidants·Mariona JovéReinald Pamplona
Oct 7, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Marko D ProkićBranka R Gavrilović
Apr 27, 2013·The Journal of Experimental Biology·José Pablo Vázquez-MedinaRudy M Ortiz
Jul 24, 2021·Seizure : the Journal of the British Epilepsy Association·Mazyar Yazdani, Katja Benedikte Prestø Elgstøen

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