PMID: 6974740Sep 1, 1981Paper

Effects of fatigue and altered pH on isometric force and velocity of shortening at zero load in frog muscle fibres

Journal of Muscle Research and Cell Motility
K A Edman, A R Mattiazzi

Abstract

temporaria (0.9-2.5degrees C) were stimulated to produce a 1 s isometric tetanus at regular intervals until constant mechanical responses were attained. Various degrees of force depression ("fatigue") were produced by decreasing the contraction interval from 30 or 15 min (control to 120, 60, 30 and 15s, respectively. In this was the steady-state tetanic force could be reversibly reduced to approximately 70% of the control value. The velocity of shortening at zero load, V0, was determined at each level of fatigue using an approach for direct measurement of V0. V0 was not significantly affected as long as the decrease in force was less than 10%. With further reduction of the isometric tension there was a progressive decline of V0 according to the following empirical relationship between percentage depression of force (delta P0) and maximum speed (delta V0) of shortening: delta V0 = 0.006 delta P02.48- 1.0 (correlation coefficient, 0.86). Cine photographic recording of nylon markers on the fibre surface provided evidence that fatigue developed uniformly along the fibre with no sign of failure of excitation in any segment. The change in mechanical performance during fatigue could be reproduced inthe non-fatigued fibre by reducing t...Continue Reading

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Citations

Jun 1, 1992·The American Journal of Physiology·L V ThompsonR H Fitts
Feb 1, 1984·Journal of Muscle Research and Cell Motility·R J Barsotti, T M Butler
Nov 29, 2002·American Journal of Physiology. Cell Physiology·Christina KaratzaferiRoger Cooke
Jan 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Douglas A Syme, Dillon M Tonks
Mar 5, 2004·American Journal of Physiology. Cell Physiology·T Radzyukevich, K A P Edman
Jun 17, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Rene Vandenboom
Aug 8, 2009·Journal of Applied Physiology·Seung Jun Choi, Jeffrey J Widrick
Jan 22, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael J GreenbergJeffrey R Moore
Nov 28, 2013·The Journal of General Physiology·Chun Y Seow
Oct 1, 1994·Acta Physiologica Scandinavica·F Lou, Y B Sun
Dec 1, 1996·Journal of Muscle Research and Cell Motility·F VawdaM A Geeves
Aug 1, 1997·Journal of Applied Physiology·O VerbitskyE Isakov
Feb 16, 2002·European Journal of Biochemistry·Gábor HildBéla Somogyi
Mar 11, 2011·Journal of Sports Sciences·Juan Manuel García-MansoMiriam Quiroga
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Mar 25, 2004·The Japanese Journal of Physiology·Shin-ichi MiyakeTeizo Tsuchiya
Dec 2, 2011·Journal of Biomedicine & Biotechnology·Sayaka HiguchiHideaki Fujita
Jun 1, 1992·The American Journal of Physiology·L V ThompsonR H Fitts
Oct 1, 1991·Journal of Muscle Research and Cell Motility·M C GarciaM Rozycka
Nov 25, 2000·Journal of Applied Physiology·B T AmeredesG C Sieck
May 16, 2008·American Journal of Physiology. Cell Physiology·E P DeboldD M Warshaw
Dec 29, 2007·Journal of Applied Physiology·Robert H Fitts
Oct 30, 2014·European Journal of Applied Physiology·Jason C SieglerSimon Green

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