Effects of fatty acids on growth and envelope proteins of Bacillus subtilis.

Journal of Bacteriology
C W Sheu, E Freese


Fatty acids of different chain lengths were added to cultures of Bacillus subtilis growing in nutrient sporulation medium, and the effects of these fatty acids on growth, oxygen uptake, adenosine triphosphate (ATP) concentration, and membrane protein composition were examined. All fatty acids inhibited growth, the effect being reduced in the presence of glycolytic compounds and reversed by transfer to medium without fatty acids. The inhibition of growth was correlated with a reduction in both the rate of oxygen consumption and the concentration of ATP per cell. The concentration required to obtain a certain degree of inhibition increased with decreasing molecular weight of the fatty acid. However, the reduced nicotinamide adenine dinucleotide oxidation system of cell envelope preparations (i.e., the electron transport system) was not inhibited. Submaximal growth inhibition was accompanied by the relative increase of a membrane protein band revealed by urea-acetic acid gel electrophoresis. This increase was blocked by actinomycin or chloramphenicol. All of the above changes could also be produced by 2,4-dinitrophenol. The inhibition results are best explained by assuming that the fatty acids reversibly react with the cell membra...Continue Reading


Jun 3, 1969·Biochimica Et Biophysica Acta·I Kahane, S Razin
Oct 1, 1968·Journal of Bacteriology·R Schmitt, E Freese
Jul 27, 1970·Biochemical and Biophysical Research Communications·P H Patterson, W J Lennarz
Sep 10, 1968·Archives of Biochemistry and Biophysics·C W CotmanT E Hugli
Oct 18, 1965·Biochimica Et Biophysica Acta·M R Salton, J H Freer
Aug 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·M N CAMIEN, M S DUNN
Aug 27, 1962·Biochimica Et Biophysica Acta·P BORSTE C SLATER
Feb 1, 1955·Archives of Biochemistry and Biophysics·F E SAMSOND L HARRIS
May 1, 1961·Plant Physiology·J E Leggett
Jun 12, 1948·Nature·W J NICKERSON, L J MULLINS

❮ Previous
Next ❯


Nov 1, 1985·The Journal of Applied Bacteriology·J C Blocher, F F Busta
Dec 1, 1973·The Journal of Applied Bacteriology·H Galbraith, T B Miller
Dec 4, 2009·Applied Microbiology and Biotechnology·Andrew P Desbois, Valerie J Smith
Jun 1, 2018·Critical Reviews in Food Science and Nutrition·Olívia Gonçalves Leão CoelhoRita de Cássia Gonçalves Alfenas
Oct 1, 1975·CRC Critical Reviews in Microbiology·W R Finnerty, R A Makula
Apr 13, 2018·International Journal of Molecular Sciences·Bo Kyeong YoonNam-Joon Cho
Dec 10, 2020·Clinical and Molecular Hepatology·Erica Jennison, Christopher D Byrne
Nov 11, 2019·Reviews in Endocrine & Metabolic Disorders·Marc Schoeler, Robert Caesar
Jun 8, 2018·Journal of Oleo Science·Toshiya MorikawaYoshimune Nonomura
Sep 29, 2017·The Journal of Microbiology·Xi-Hui Li, Joon-Hee Lee
Aug 1, 1977·Infection and Immunity·R D MillerS A Morse
Dec 1, 1979·Infection and Immunity·D P SpeertC C Clawson
Mar 1, 1975·Antimicrobial Agents and Chemotherapy·C W SheuE Freese
Mar 1, 1980·Journal of Bacteriology·D D Carson, L Daneo-Moore
May 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ke XueChunlei Zhu
Oct 1, 1993·Applied and Environmental Microbiology·F J WeberJ A de Bont
Feb 1, 1976·Applied and Environmental Microbiology·J P Fay, R N Farías
Dec 1, 1975·Bacteriological Reviews·H L Sadoff
Feb 1, 1981·Food and Cosmetics Toxicology·D L Opdyke
Aug 1, 1984·Antimicrobial Agents and Chemotherapy·H SaitoT Yoneyama

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.