Effects of feeding state on anticoagulation in adult goats treated with warfarin

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
Kazuma DateEisuke Tatsumi

Abstract

For the continued development of improved mechanical circulatory systems, longer term evaluation of new devices in animal model experiments may be critical. The effects of anticoagulants in adult goats have not been well studied. We assessed the effects of oral warfarin in three adult goats during fasting or after feeding. The goats [weighing 57.8 ± 8.1 kg (53.0-67.2 kg)] were administered warfarin orally beginning at a dose of 5 mg/day and then increasing to 10, 20, 40, and 60 mg every 2 weeks. One goat (receiving 10 mg/day warfarin) was killed on day 27 because of the inability to stand. After administration of 60 mg warfarin, the remaining goat received no warfarin for 4 days to return to coagulated state. The goats were then fasted and treated with 40 mg warfarin. During warfarin administration, both goats required a dose of 60 mg/day to achieve International Normalized Ratios (INRs) of approximately 2.5; however, when, the animals were in the fasted condition, precipitous extension of INR was observed in 5 days. After resuming feeding, the INR was reduced to the proper range. We showed the tendency that warfarin therapy in goats required higher doses than the doses administered to human patients and that the effects of the...Continue Reading

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Citations

Nov 28, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Noritsugu NaitoEisuke Tatsumi
Sep 14, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Satoru KishimotoEisuke Tatsumi
Sep 6, 2021·International Journal of Clinical Practice·Abdulrahman AlwhaibiMohamed Al-Arifi

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