Effects of felbamate on veratridine- and K(+)-stimulated release of glutamate from mouse cortex

European Journal of Pharmacology
J SrinivasanJ A Davies

Abstract

Felbamate is a novel anticonvulsant which may modulate the strychnine-insensitive glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. This study examined the effect of felbamate and 5,7-dichlorokynurenic acid on veratridine (20 microM)- and K+ (60 mM)-stimulated release of amino acids in mouse cortical slices. Felbamate significantly decreased veratridine-induced release of glutamate at 400 microM and 800 microM but had no effect on K(+)-stimulated release. 5,7-Dichlorokynurenic acid had no effect on amino-acid release in concentrations up to 200 microM. The inhibitory effect of felbamate on veratridine-induced release of glutamate may be due to inactivation of voltage-sensitive Na+ channels.

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Citations

Jul 13, 2001·Pharmacology & Therapeutics·P KwanM J Brodie
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Serena SilvestroEmanuela Mazzon

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