Effects of fenofibrate on high-fat diet-induced body weight gain and adiposity in female C57BL/6J mice

Metabolism: Clinical and Experimental
Sunhyo JeongMichung Yoon

Abstract

Our previous study suggested that fenofibrate affects obesity and lipid metabolism in a sexually dimorphic manner in part through the differential activation of hepatic peroxisome proliferator-activated receptor alpha (PPARalpha) in male and female C57BL/6J mice. To determine whether fenofibrate reduces body weight gain and adiposity in female sham-operated (Sham) and ovariectomized (OVX) C57BL/6J mice, the effects of fenofibrate on not only body weight, white adipose tissue (WAT) mass, and food intake, but also the expression of both leptin and PPARalpha target genes were measured. Compared to their respective low-fat diet-fed controls, both Sham and OVX mice exhibited increases in body weight and WAT mass when fed a high-fat diet. Fenofibrate treatment decreased body weight gain and WAT mass in OVX, but not in Sham mice. Furthermore, fenofibrate increased the mRNA levels of PPARalpha target genes encoding peroxisomal enzymes involved in fatty acid beta-oxidation, and reduced apolipoprotein C-III (apo C-III) mRNA, all of which were expressed at higher levels in OVX compared to Sham mice. However, leptin mRNA levels were found to positively correlate with WAT mass, and food intake was not changed in either OVX or Sham mice foll...Continue Reading

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Citations

Feb 5, 2011·Acta Pharmacologica Sinica·Sunhyo Jeong, Michung Yoon
Jun 21, 2005·Journal of Cardiovascular Pharmacology·Vanessa DeclercqMohammed H Moghadasian
Sep 28, 2010·PPAR Research·Michung Yoon
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Aug 4, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Michung Yoon
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Jun 15, 2006·The Journal of Nutrition·Samuel SerisierPatrick Nguyen
Oct 6, 2020·Journal of Nutrition and Metabolism·Cuellar-Rufino SergioArroyo-Helguera Omar
Mar 20, 2021·Antioxidants & Redox Signaling·Andrea Morán-CostoyaAdamo Valle
May 1, 2021·International Journal of Molecular Sciences·Yujin ShinMichung Yoon
Jun 8, 2021·Journal of Veterinary Internal Medicine·Matthew J L MunroChen Gilor
Jun 16, 2021·Nature Reviews. Cardiology·David MontaigneBart Staels

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