Effects of fenoldopam on renal blood flow in hypertensive chronic kidney disease.

Journal of Nephrology
Valentina RovellaAnnalisa Noce

Abstract

The synthetic drug fenoldopam mesylate (FM) may have a renoprotective role, and a "renal dose" of 0.1 µg/kg/min intravenous (IV) infusion of FM has been reported as able to increase renal blood flow without affecting systemic blood pressure. But conclusive data are still lacking. We aimed to investigate by color-Doppler ultrasonography the effects of IV administration of FM at this dosage in hypertensive chronic kidney disease (CKD) patients, and verify whether it may induce any systemic hemodynamic alteration. In 60 hypertensive CKD patients, we measured by duplex Doppler ultrasonography, at baseline and during infusion of 0.1 µg/kg/min of FM, the systolic and diastolic flow velocity (sampled at the renal hilum, intermediate section and origin of both renal arteries) and the intra-parenchymal renal resistive index (RRI) sampled on interlobular arteries of both kidneys. Patients were divided into four subgroups (I-IV) according to classification of National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-DOQI). Infusion of 0.1 µg/kg/min FM significantly decreased the RRI (0.73 ± 0.05 vs. 0.65 ± 0.06; p < 0.0001) and increased the systolic and diastolic flow velocities in all renal artery tracts examined. No si...Continue Reading

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Citations

May 1, 2019·Current Pharmaceutical Biotechnology·Annalisa NoceNicola Di Daniele
Dec 13, 2018·Journal of Nephrology·Pierpaolo Di Nicolò, Antonio Granata
Jan 13, 2021·Néphrologie & thérapeutique·Mouad HamzaouiDominique Guerrot
May 19, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gianluigi ArdissinoUNKNOWN ItalKid-HUS Network

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