PMID: 9660269Jul 11, 1998Paper

Effects of fenoldopam on systemic and splanchnic haemodynamics and oxygen delivery/consumption relationship during hyperdynamic ovine endotoxaemia

Intensive Care Medicine
I M SchwiegerD R Morel

Abstract

To evaluate the use of a selective dopamine-1 agonist (fenoldopam) to provide selective splanchnic vasodilatation during sustained hypotensive endotoxaemia in sheep. Randomised, controlled, experimental study. Animal research laboratory. 12 adult instrumented, midazolam-sedated sheep. The animals were randomised to receive a 20-min continuous infusion of dopamine (10 microg x kg(-1) x min(-1), fenoldopam (10 microg x kg(-1) x min(-1) and noradrenaline (1 microg x kg(-1) x min(-1)) under control conditions and 12 h after endotoxaemia was induced by a continuous infusion of Escherichia coli endotoxin producing a stable hyperdynamic state simulating human septic shock. This drug dosage was selected to produce a 25-30% increase in cardiac output by all three drugs during control conditions. Systemic and splanchnic haemodynamic data were continuously obtained and systemic and splanchnic oxygen delivery (DO2) and consumption (VO2) were calculated. Hyperdynamic hypotensive endotoxaemia did not modify the splanchnic and renal reduction in DO2 and the vasoconstrictive reactivity to noradrenaline observed during control conditions. In contrast, endotoxaemia abolished the fenoldopam and dopamine-induced increase in splanchnic DO2 (especia...Continue Reading

Citations

May 9, 2002·Expert Opinion on Investigational Drugs·Sheila A Doggrell
Mar 12, 2011·Anesthesiology·Johan FenhammarRobert Frithiof
Aug 27, 2004·Anesthesiology·Andrea MorelliPaolo Pietropaoli
Mar 23, 2002·International Anesthesiology Clinics·Elamana Vijayakumar
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Jean-Jacques Boffa, William J Arendshorst
Apr 6, 2007·American Journal of Physiology. Renal Physiology·Akanksha GuptaBrian W Grinnell
Oct 26, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jorge A GuzmanJames A Kruse
Jul 18, 2001·Journal of Applied Physiology·J A GuzmanJ A Kruse

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