Effects of fentanyl infusion on tracheal intubation and emergence agitation in preschool children anaesthetized with sevoflurane

British Journal of Anaesthesia
S InomataM Tanaka

Abstract

Sevoflurane can be used as a sole agent for intubation in children, but studies have suggested that it is associated with emergence agitation. Fentanyl infusions can be used both to facilitate intubation and decrease emergence agitation. We investigated the effects of fentanyl on conditions at intubation and on emergence from sevoflurane anaesthesia without confounding nitrous oxide or premedication. IRB approval and informed consent were obtained. Subjects comprised 150 ASA physical status I or II (age, 2-6 yr). Anaesthesia was induced with sevoflurane in oxygen and maintained using a predetermined concentration of sevoflurane. Subjects were randomly allocated to receive one of three doses of fentanyl: vehicle only (control group), a bolus dose of 1 microg kg(-1) followed by a continuous infusion of 0.5 microg kg(-1) h(-1) (F1 group), or a bolus dose of 2 microg kg(-1) followed by a continuous infusion of 1 microg kg(-1) h(-1) (F2 group). Sevoflurane minimum alveolar concentration for tracheal intubation (MAC(TI)) and emergence agitation score were assessed. MAC(TI) values were 2.49%, 1.61%, and 1.16% in control, F1, and F2 groups, respectively (P<0.05). Agitation scores were 11.5, 7.0, and 2.6 in control, F1, and F2 groups, r...Continue Reading

References

Feb 1, 1995·Journal of Clinical Anesthesia·J A Aldrete
Jul 20, 1999·Paediatric Anaesthesia·S L LapinA M Reynolds
Sep 3, 1999·British Journal of Anaesthesia·T KatohK Ikeda
Jan 5, 2000·British Journal of Anaesthesia·J B Rose, M F Watcha
Nov 30, 2000·British Journal of Anaesthesia·S InomataH Toyooka
Mar 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ying Li, Anthony N van den Pol

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Citations

Jan 22, 2014·Anaesthesia·M AbdulatifS Badawy
Feb 25, 2015·Journal of Research in Pharmacy Practice·Anindya MukherjeeRaghunath Bhattacharyya
Sep 13, 2014·The Cochrane Database of Systematic Reviews·David CostiPhilippa Middleton
Nov 1, 2016·Paediatric Drugs·Arthura D Moore, Doralina L Anghelescu
Mar 27, 2020·Korean journal of anesthesiology·Seok-Jin Lee, Tae-Yun Sung

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