Effects of fetal alcohol exposure on fever, sickness behavior, and pituitary-adrenal activation induced by interleukin-1 beta in young adult rats

Brain, Behavior, and Immunity
R YirmiyaA N Taylor

Abstract

Exposure to alcohol in utero can lead to long-lasting impairments of immune functions and to decreased resistance to infectious agents. We have previously reported that fetal alcohol-exposed rats show markedly decreased lipopolysaccharide-induced fever and suggested that fetal alcohol exposure (FAE) impairs the communication between the immune and the nervous systems. The present study examined the effects of interleukin-1 beta (IL-1) on body temperature, motor activity, ingestive behavior, and pituitary-adrenal activation in fetal alcohol-exposed and control rats. Transmitters for continuous biotelemetric recording of body temperature and motor activity were implanted i.p. in normal (N) adult rats, offspring of dams fed a liquid diet supplemented with ethanol (E), and pair-fed control offspring (P). In one experiment, rats were injected with either IL-1 (2 micrograms/kg, i.p.) or saline at the beginning of the light period. IL-1 produced a marked increase in body temperature, which was significantly lower in E rats than in N and P rats. In a second experiment, rats were administered either IL-1 (10 micrograms/kg, i.p.) or saline at the beginning of the dark period. IL-1 produced an initial transient hypothermia followed by a l...Continue Reading

Citations

Feb 1, 2002·Alcoholism, Clinical and Experimental Research·Anna N TaylorRaz Yirmiya
May 4, 2011·The Psychiatric Clinics of North America·Sarah Shizuko Morimoto, George S Alexopoulos
Mar 4, 2011·International Journal of Geriatric Psychiatry·George S Alexopoulos, Sarah Shizuko Morimoto
Dec 14, 2004·Journal of Neuroimmunology·Anna N TaylorHoracio E Romeo
Apr 20, 2006·Behavioural Brain Research·Lisa M Thomson, Robert J Sutherland
Jul 27, 2012·Developmental Neuroscience·Abdeslam Mouihate, Mouihate Abdeslam
Jan 11, 2017·Alcoholism, Clinical and Experimental Research·Tatiane M B B TellesAleksander R Zampronio
Apr 14, 2007·Breast Cancer Research and Treatment·Yossi SchwartzShamgar Ben-Eliyahu
Jun 20, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Natasha ReidLisa K Akison
Aug 17, 2002·Journal of Applied Physiology·Christian K RobertsR James Barnard
Jun 16, 2005·Experimental Biology and Medicine·Xingqi ZhangJoanne Weinberg

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