PMID: 6109753Jan 1, 1981Paper

Effects of fetal treatment with methylazoxymethanol acetate at various gestational dates on the neurochemistry of the adult neocortex of the rat

Journal of Neurochemistry
M V JohnstonJ T Coyle

Abstract

The effects of gestational date (13, 14, 15, and 17 days) or administration of methylazoxymethanol acetate (20 mg/kg) on the cortical synaptic chemistry and morphology of the rat has been examined in adult offspring. Treatment at 13 days of gestation (DG) resulted in cortical hypoplasia that affected primarily the deep layers whereas treatment at 14 and 15 days gestation caused a severe hypoplasia of cortical neurons above layer V and a 66 to 77% reduction in cortical mass. The 17-DG treatment caused only a 20% reduction in cortical weight with effects apparent only in the superficial layers. At no treatment date did the specific activity of glutamate decarboxylase differ significantly from control. In contrast, presynaptic markers for noradrenergic (tyrosine hydroxylase and norepinephrine) and for serotonergic (serotonin) terminals were increased in concentration in direct proportion to the degree of cortical hypoplasia. The specific activity of choline acetyltransferase was significantly increased at all treatment dates but total activity per cortical slab was significantly reduced on treatment days 13-15.

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M V JohnstonJ T Coyle
Oct 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·Y Nagata, H Matsumoto
Dec 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·M Spatz, G L Laqueur

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Citations

Jan 1, 1996·Neurobiology of Aging·F DragoU Scapagnini
May 13, 1998·Mechanisms of Ageing and Development·S CiaroniP Del Grande
Feb 17, 2000·Brain Research. Developmental Brain Research·M V PletnikovT H Moran
Oct 9, 1999·Epilepsy Research·K M JacobsD A Prince
Apr 14, 2015·Developmental Psychobiology·Gale A Kleven, Seanceray A Bellinger
Jul 15, 2004·Behavioural Pharmacology·R GourevitchT M Jay
May 20, 2004·Psychiatry and Clinical Neurosciences·Kiyotaka HashizumeTatsuya Tanaka
Jul 29, 2020·Frontiers in Psychiatry·Susan F SonnenscheinAnthony A Grace
Nov 11, 2020·Expert Opinion on Therapeutic Targets·Susan F Sonnenschein, A Grace
Jan 1, 1983·Journal of Neuroscience Research·M Beaulieu, J T Coyle

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