Effects of FGF-2 on metaphyseal fracture repair in rabbit tibiae

Journal of Bone and Mineral Metabolism
Wei-Jia ChenYukihide Iwamoto

Abstract

Fibroblast growth factor-2 (FGF-2) has been found to have stimulatory effects on fracture repair at diaphysis, while its effect on metaphyseal fracture repair, where spongiosal bone is dominant, has not been studied. This study was conducted to investigate the effect of FGF-2 on metaphyseal fracture healing in a rabbit proximal tibial metaphyseal model. The proximal tibial metaphysis of 6-month-old Japanese white rabbits was osteotomized bilaterally. Then 400 microg of FGF-2, mixed with gelatin hydrogel, and gelatin hydrogel alone (the control) were injected to each osteotomy site of the rabbit proximal tibiae, and the osteotomies were fixed with staples. One and 2 weeks after surgery, the osteoid area in the repairing spongiosal bone at the fracture site was significantly larger in the FGF-2 group than in the control group ( P < 0.05). On immunohistochemistry, proliferating-cell nuclear antigen-positive cells had a tendency to show greater numbers in the FGF-2 group. After 4 and 8 weeks, values for bone mineral density and the cancellous bone area in the healing region of the fracture site were significantly larger in the FGF-2 group ( P < 0.05). These data suggest that local application of FGF-2 may have an accelerating effec...Continue Reading

Citations

Aug 21, 2013·International Orthopaedics·Xin WangShibi Lu
Oct 19, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tsuyoshi GotoToshikazu Kubo
Dec 2, 2008·La Chirurgia degli organi di movimento·Valentina DevescoviElisabetta Cenni
Nov 3, 2010·Acta Pharmacologica Sinica·Elisabetta CenniNicola Baldini
Jan 26, 2011·The Journal of Biological Chemistry·Matthew D KwanMichael T Longaker
Dec 19, 2013·Trauma Monthly·Hooman BakhshiFarshad Safdari
May 27, 2014·Injury·Ippokratis PountosPeter V Giannoudis
Apr 15, 2011·Injury·Kurt D HankensonMara Schenker
Mar 27, 2007·Injury·Peter GiannoudisGeorge Kontakis
Aug 19, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Uwe MausChristopher Niedhart
Sep 19, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Donatella GranchiNicola Baldini
May 28, 2010·Journal of Cellular Biochemistry·Samir M AbdelmagidFayez F Safadi
Mar 2, 2012·Journal of Cellular Physiology·Xiaolan DuLin Chen
Aug 16, 2013·Journal of Biomedical Materials Research. Part a·Janin ReifenrathSilke Besdo
Sep 16, 2008·Biochemical and Biophysical Research Communications·Nan SuLin Chen
Aug 14, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Gui-Ke ZouWen-Zhong Zhu
Feb 27, 2016·Clinical Oral Implants Research·Toshie Nagayasu-TanakaShinya Murakami
Sep 29, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ayumi SakamotoMuneki Honnami
Aug 23, 2006·Journal of Cellular Biochemistry·Shu Jun SongVictor Nurcombe
May 18, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eleftherios TsiridisPaul Tornetta
Jun 27, 2018·Journal of the Endocrine Society·J Douglas CoffinMarja Marie Hurley
May 25, 2006·The Journal of Bone and Joint Surgery. British Volume·A H R W SimpsonB Noble
Aug 6, 2020·Nanomaterials·Shuai YueTao Hou
Jul 12, 2019·World Journal of Stem Cells·Diane R WagnerJiliang Li
Jun 10, 2019·Clinical Hemorheology and Microcirculation·Rebecca RotheJens Pietzsch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.