Effects of fibrin glue on injured rabbit ureter

Journal of Endourology
U KumarT M Turk

Abstract

Fibrin glue is used as a hemostatic agent, has potential as a tissue adhesive, and may promote tissue healing. The histologic effects of fibrin glue on the ureter have not yet been fully investigated. We studied the effect of fibrin glue on the thickness of various layers of injured and uninjured ureters and its effect on vessel density in the rabbit model. Rabbits were divided into two groups. The ureters were exposed using a midline abdominal incision. In the study group, one of the ureters was crushed, and fibrin glue was instilled around both ureters. In the control group, one of the ureters was crushed, but no fibrin glue was instilled. The animals were sacrificed at 6 weeks and the ureters examined histologically. Using NIH Image Analysis solftware, the thickness of the urothelium, muscular, and adventitial layers and the cross-sectional area of the ureters were measured. The vessel density of the ureters was also assessed. Whereas the thickness of the epithelium was increased in the crushed ureters treated with fibrin glue (20.7 microm v 15.3 microm), the thickness was reduced in the uncrushed ureters treated with fibrin glue compared with controls (16.3 microm v 19.8 microm). There was no statistically significant diffe...Continue Reading

References

Apr 1, 1992·Archives of Surgery·D M BrownB A Pruitt
Nov 1, 1994·The Journal of Urology·T C McKayM Castelli
Aug 1, 1996·British Journal of Urology·C G Eden, M J Coptcoat
Oct 6, 1997·British Journal of Urology·C G EdenR K Carruthers

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Citations

May 9, 2003·Urology·Albert A MikhailGary C Bellman
Feb 5, 2010·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Bruno M T PereiraMark G McKenney
Mar 31, 2006·Journal of the American College of Surgeons·David M Albala, Jeffrey H Lawson

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