PMID: 2500167Apr 29, 1989Paper

Effects of fibrinolytic inhibitors on mortality from upper gastrointestinal haemorrhage

BMJ : British Medical Journal
D A Henry, D L O'Connell

Abstract

To see whether fibrinolytic inhibitors are of value when given to patients with upper gastrointestinal haemorrhage. Meta-analysis of six randomised double blind placebo controlled trials. Two methods used for obtaining an overall estimate of effect, including a random effects model incorporating any heterogeneity of outcome in the estimate of the overall treatment effect. Inpatient care in hospitals in the United Kingdom, Sweden, and Australia. 1267 Patients admitted to hospital with primary diagnosis of acute upper gastrointestinal haemorrhage. Five of the six trials included a high proportion of elderly patients. Most patients were bleeding from peptic ulcers in the stomach and duodenum (43-88%) or gastric erosions (4-23%). A variable proportion had a degree of clinical shock at entry. Tranexamic acid 3-6 g/day given intravenously for two or three days followed by 3-6 g/day by mouth for a further three to five days (four trials) or 4.5-12 g/day by mouth for two to seven days (two trials). Frequency of recurrent haemorrhage, need for surgery, and death. Treatment with tranexamic acid was associated with a 20-30% reduction in the rate of rebleeding, a 30-40% reduction (95% confidence interval 10% to 60%) in mortality. Treatment...Continue Reading

References

Jan 1, 1979·Scandinavian Journal of Gastroenterology·A EngqvistJ E Wedlund
Mar 1, 1985·Progress in Cardiovascular Diseases·S YusufP Sleight
Jan 1, 1987·Statistics in Medicine·R J Simes
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Feb 19, 1987·The New England Journal of Medicine·H S SacksT C Chalmers
Jun 2, 1973·Lancet·F CormackG R Fearnley
Jun 30, 1983·The New England Journal of Medicine·D BarerM Langman
Aug 16, 1984·The New England Journal of Medicine·M VermeulenJ van Gijn
Nov 24, 1983·The New England Journal of Medicine·T C Chalmers
Jan 1, 1980·Upsala Journal of Medical Sciences·D BergqvistY Hessman
Jun 1, 1955·Annals of Human Genetics·B WOOLF

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Citations

Oct 24, 2006·European Radiology·Stephen J BurkeShiliang Sun
Jul 29, 2005·Digestive Diseases and Sciences·Venodhar R Julapalli, David Y Graham
Mar 30, 2007·Current Treatment Options in Gastroenterology·Grigoris I Leontiadis, Colin W Howden
Sep 15, 1994·The New England Journal of Medicine·L Laine, W L Peterson
Jul 23, 1998·The New England Journal of Medicine·P M Mannucci
Jun 17, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miso SabovicBojan Vujkovac
Mar 29, 2001·Journal of Clinical Gastroenterology·A GutiérrezM Pérez-Mateo
Oct 24, 2002·Current Opinion in Hematology·Jason ChiuThomas J Reid
Mar 6, 2003·Vox Sanguinis·Paul M Ness
Aug 10, 1991·BMJ : British Medical Journal·D A Henry
Jan 18, 1992·BMJ : British Medical Journal·C Brown, W D Rees
Feb 8, 1992·BMJ : British Medical Journal·D Barer
Jul 1, 1991·Postgraduate Medical Journal·S C Jones, A T Axon
Jan 1, 1993·Postgraduate Medical Journal·B Kaufman, A Wise
Jan 2, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alan T TinmouthRobert A Fowler
Oct 9, 2008·Drugs·Thomas O G Kovacs, Dennis M Jensen
Sep 22, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Chee Ching ChanFaiz Tanweer
May 10, 2013·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerPiet Wyffels
Mar 20, 2013·Medicina intensiva·S R Leal-NovalUNKNOWN Sociedades Españolas de Anestesiología y Reanimación (SEDAR), Hematología y Hemoterapia (SEHH), Farmacia Hospitalaria (SEFH)
Feb 19, 2013·Revista española de anestesiología y reanimación·S R Leal-NovalA Puppo
Oct 19, 2010·Gastroenterology Clinics of North America·Joshua Greenspoon, Alan Barkun
Aug 4, 2010·Journal of Pain and Symptom Management·Seth B RobertsLaurel J Lyckholm
Mar 19, 2008·Best Practice & Research. Clinical Gastroenterology·F H Klebl, J Schölmerich
Mar 11, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M PrimignaniM Cattaneo
Nov 14, 2015·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Hitendra GargS L Broor
Jul 17, 2007·Journal of the Neurological Sciences·Katja E Wartenberg, Stephan A Mayer
Feb 6, 2008·Alimentary Pharmacology & Therapeutics·L L GluudS E Langholz
Jan 24, 2006·Seminars in Hematology·Stephan A Mayer, Fred Rincon
Aug 23, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·M J Langman
Jun 3, 2016·African Journal of Paediatric Surgery : AJPS·Mandana RafeeyRobabeh Ghergherechi
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·J J Kolkman, S G Meuwissen
Jul 11, 2007·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Farrukh Awan, Mehdi Hamadani
Mar 14, 2007·Scandinavian Journal of Gastroenterology·Sven AdamsenPeer Wille-Jørgensen
Dec 14, 1999·Alimentary Pharmacology & Therapeutics·A N BarkunR N Fedorak
Jun 11, 2015·The Cochrane Database of Systematic Reviews·Arturo J Martí-Carvajal, Ivan Solà
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Stephan A Mayer
Jan 1, 1993·Postgraduate Medical Journal·T Masud, K Somerville
Nov 22, 2014·The Cochrane Database of Systematic Reviews·Cathy BennettLise Lotte Gluud
Jul 1, 1994·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·C M Olson
Apr 1, 1993·Alimentary Pharmacology & Therapeutics·L Laine

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