Effects of fibrous and non-fibrous dusts on Chinese hamster V79 cells: Cytotoxicity or cytostasis?

Toxicology in Vitro : an International Journal Published in Association with BIBRA
S O LockJ V Friend

Abstract

Chinese hamster V79 (CHV79) cells cultured in vitro were used to study the cytopathic effects of seven mineral dusts (four of which were fibrous). Lactate dehydrogenase release and the incorporation of [(3)H]thymidine into DNA were used to study toxic and static interactions, respectively. Crystalline silica dusts had a toxic effect on the cells. In contrast, Canadian chrysotile (chrysotile 'B') was relatively non-toxic but principally had a static effect upon CHV79 cells. Amphibole asbestos dusts demonstrated mainly static properties, albeit less marked than with chrysotile, and some toxic properties. Titanium dioxide was neither toxic nor static in vitro.

References

May 1, 1978·Mutation Research·S L HuangH V Malling
Dec 1, 1978·International Journal of Cancer. Journal International Du Cancer·R C BrownV Timbrell
Oct 1, 1975·Environmental Research·K S LavappaS S Epstein
Mar 1, 1974·British Journal of Cancer·J C WagnerV Timbrell
Dec 1, 1974·Environmental Health Perspectives·F PottK H Friedrichs
Dec 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·E H Chu, H V Malling
Jan 1, 1980·Toxicology·R C BrownG T Sutton
Oct 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·F WROBLEWSKI, J S LADUE

❮ Previous
Next ❯

Citations

Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·V Bianchi, E Fortunati
Sep 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K PelinK Linnainmaa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicology in Vitro : an International Journal Published in Association with BIBRA
K PelinK Linnainmaa
Toxicology in Vitro : an International Journal Published in Association with BIBRA
C FlowerD Anderson
Toxicology in Vitro : an International Journal Published in Association with BIBRA
T W HesterbergP Nettesheim
Toxicology in Vitro : an International Journal Published in Association with BIBRA
R C BrownC Vann
© 2021 Meta ULC. All rights reserved