PMID: 11330612May 2, 2001Paper

Effects of finasteride on size of the prostate gland and semen quality in dogs with benign prostatic hypertrophy

Journal of the American Veterinary Medical Association
Kaitkanoke SirinarumitrM A Memon

Abstract

To determine the effect of the 5alpha-reductase inhibitor finasteride on prostatic diameter and volume, semen quality, and serum dihydrotestosterone (DHT) and testosterone concentrations in dogs with spontaneous benign prostatic hypertrophy (BPH). Double-blind placebo-controlled trial. 9 dogs with BPH. Five dogs were treated with finasteride for 16 weeks (0.1 to 0.5 mg/kg [0.05 to 0.23 mg/lb] of body weight, PO, q 24 h); the other 4 received a placebo. Prostatic diameter, measured radiographically, prostatic volume, measured ultrasonographically, semen quality, and serum DHT and testosterone concentrations were evaluated before and during treatment. After receiving the placebo for 16 weeks, the 4 control dogs were treated with finasteride for 16 weeks, and evaluations were repeated. Finasteride significantly decreased prostatic diameter (mean percentage decrease, 20%), prostatic volume (mean percentage decrease, 43%), and serum DHT concentration (mean percentage decrease, 58%). Finasteride decreased semen volume but did not adversely effect semen quality or serum testosterone concentration. No adverse effects were reported by owners of dogs in the study. Results suggest that finasteride can be used to reduce prostatic size in d...Continue Reading

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Citations

Mar 24, 2004·Theriogenology·Y CorradaC Gobello
May 18, 2007·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Noriyuki Masuda, Masanori Suzuki
Apr 10, 2002·American Journal of Veterinary Research·Kaitkanoke SirinarumitrMargaret V Root Kustritz
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