Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens

The British Journal of Nutrition
Bettina KönigKlaus Eder

Abstract

In mammals, (n-3) PUFA and conjugated linoleic acids (CLA) act as activators of PPAR alpha and alter nuclear concentrations of sterol regulatory element-binding proteins (SREBP) in the liver, and thereby influence hepatic lipid catabolism and synthesis. In this study, we investigated the hypothesis that (n-3) PUFA and CLA exert similar effects in the liver of laying hens. Thirty hens (64 weeks old) were fed diets containing 30 g/kg of sunflower oil (control), fish oil (salmon oil) or CLA in TAG form (containing predominantly cis-9, trans-11 CLA and trans-10, cis-12 CLA) for 5 weeks. Hens fed fish oil had a higher expression of some PPAR alpha target genes and a lower nuclear concentration of SREBP-2 in the liver and lower concentrations of cholesterol and TAG in plasma than control hens. Nuclear concentration of SREBP-1 and its target genes involved in lipogenesis were not altered in hens fed fish oil. Hens fed CLA had increased concentrations of TAG and cholesterol in the liver. However, their mRNA levels of PPAR alpha target genes and nuclear concentrations of SREBP-1 and SREBP-2 as well as mRNA levels of their target genes in the liver were largely unchanged compared to control hens. The results of this study suggest that (n...Continue Reading

References

Oct 1, 1978·Analytical Biochemistry·A Hara, N S Radin
Nov 10, 1998·Circulation·B StaelsJ C Fruchart
Jan 30, 1999·Journal of Molecular Endocrinology·P R Holden, J D Tugwood
Mar 4, 1999·The Journal of Nutrition·R L WalzemR L Hamilton
Oct 26, 1999·Endocrine Reviews·B Desvergne, W Wahli
Sep 8, 2000·Molecular and Cellular Biochemistry·M CastilloE García-Peregrín
Aug 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peter J EspenshadeDaisuke Yabe
Sep 18, 2002·Journal of Lipid Research·Lionel ClémentPhilippe Besnard
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Daisuke YabeJoseph L Goldstein
Mar 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Daisuke YabeMichael S Brown
Jul 8, 2003·The British Journal of Nutrition·Beata Szymczyk, Paweł M Pisulewski
Mar 5, 2004·American Journal of Physiology. Endocrinology and Metabolism·Natesampillai Sekar, Johannes D Veldhuis
Mar 5, 2004·Cellular and Molecular Life Sciences : CMLS·S MandardS Kersten
Aug 24, 2004·The American Journal of Clinical Nutrition·Sabine TriconPhilip C Calder
Oct 12, 2004·The Biochemical Journal·Catherine Le Jossic-CorcosPaulette Bournot
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Connie W H WooKarmin O
Oct 12, 2005·The Journal of Nutritional Biochemistry·Bettina König, Klaus Eder
Jan 4, 2006·Cellular and Molecular Life Sciences : CMLS·R GeyereggerT M Stulnig
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Josep Bassaganya-Riera, Raquel Hontecillas

❮ Previous
Next ❯

Citations

Jun 17, 2014·The British Journal of Nutrition·Bérengère BenoitMarie-Caroline Michalski
May 21, 2014·International Journal of Food Sciences and Nutrition·Ming-Shyong WangHuey-Mei Shaw
Feb 20, 2019·Animals : an Open Access Journal From MDPI·Faegheh ZaefarianVelmurugu Ravindran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Pei-Min ChaoHuey-Mei Shaw
Current Diabetes Reports
Angelika Lettner, Michael Roden
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
María Dolores GirónJosé M López-Pedrosa
© 2021 Meta ULC. All rights reserved