Effects of Fish Oil on HIV-Related Inflammation and Markers of Immunosenescence: A Randomized Clinical Trial

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
Barbara SwansonAnneliese Rosdil

Abstract

To explore the safety and efficacy of fish oil to modulate parameters of inflammation and immunosenescence in HIV-infected older adults. This study uses a randomized, controlled, double-blind clinical trial. The study was conducted in an outpatient HIV/AIDS clinic in a large urban Midwestern city in the United States. A total of 37 clinically stable HIV-infected adults between the ages of 40 and 70 years of age participated. Fish oil 1.6 g/day was administered for 12 weeks or placebo. Inflammatory cytokine production, surface markers of immunosenescence, and adverse events were measured. After 12 weeks of supplementation, there were no significant differences between the treatment and control groups on any measures of inflammation or immunosenescence in both CD4+ and CD8+ T lymphocytes. More participants in the treatment group reported adverse gastrointestinal events compared with the control group. A 12-week supplementation regimen of 1.6 g/day of fish oil did not favorably modulate parameters of inflammation or immune senescence in HIV-infected adults. Future studies should test agents that directly target mechanisms that underlie HIV-related inflammation to determine whether reducing inflammation can reverse immunosenescence.

References

Mar 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M K HellersteinR A Neese
Jun 13, 1996·The New England Journal of Medicine·A BelluzziM Miglioli
Jan 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·S J BellR A Forse
Jan 5, 2000·The American Journal of Clinical Nutrition·J M Kremer
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sine Reker HadrupAnders Wikby
Sep 23, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Alice H LichtensteinJudith Wylie-Rosett
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Jan 20, 2007·Journal of Lipid Research·Robert J PawloskyNorman Salem
Mar 14, 2007·Journal of the American College of Nutrition·Luisa Deutsch
Dec 29, 2007·The Journal of Pathology·V Appay, D Sauce
Oct 28, 2010·Current Opinion in HIV and AIDS·Daniel E Nixon, Alan L Landay
Nov 26, 2010·Annual Review of Medicine·Steven G Deeks
Jan 27, 2012·The Journal of Nutrition·Philip C Calder
Jun 5, 2012·Current Opinion in Immunology·Steven G DeeksJoseph M McCune
Mar 9, 2013·Nature Reviews. Immunology·Lieping Chen, Dallas B Flies
Jul 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Philip C Calder
Dec 3, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Carey L ShiveMichael M Lederman

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Citations

Nov 22, 2018·Current Opinion in Infectious Diseases·Tess E Peterson, Jason V Baker
Jan 24, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Artur BjelicaJelena Cvejić
Dec 11, 2019·Nutrients·Urszula RadzikowskaMilena Sokolowska

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Methods Mentioned

BETA
flow cytometry
fluorescence-activated cell sorting
FACS

Clinical Trials Mentioned

NCT02102724

Software Mentioned

FlowJo
PLUS
SAS

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