Effects of fixation and preservation on tissue elastic properties measured by quantitative optical coherence elastography (OCE)

Journal of Biomechanics
Yuting LingGhulam Nabi

Abstract

Fixed and preserved tissues have been massively used in the development of biomedical equipment and instrumentation. Not only the tissue morphology, but also its mechanical properties need to be considered in the fixation and preservation procedures since mechanical properties have significant influence on the design and performance of such instruments. Understanding the effects of storage and preservation conditions on the mechanical properties of soft tissue has both clinical and experimental significance. To this end, we aimed to study the effects of tissue preservation (by 10% formalin and Thiel fluids) on the elastic properties of five different kinds of fresh tissues from pig and chicken; specifically fat, liver, muscle, tendon and cartilage. The tissue elasticity was measured intensively and strictly within a controlled timeline of 6 months by quantitative optical coherence elastography (OCE) system. Our findings suggest that the elasticity change of tissues in the formalin solution has an ascending trend, but that of Thiel remains almost constant, providing a more real texture and properties.

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Citations

Dec 23, 2016·Archives of Orthopaedic and Trauma Surgery·Philip P RoesslerTurgay Efe
Dec 19, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ling YutingGhulam Nabi
May 22, 2019·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Johann ZwirnerNiels Hammer
Mar 4, 2020·Biomedical Physics & Engineering Express·Benjamin G WoodIvan Z D Nenadic
Feb 5, 2021·Frontiers in Bioengineering and Biotechnology·Anne Metje van GenderenMiguel Castilho
Mar 11, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Sarah-Jane EstermannAndreas Reisinger

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