Effects of fixation type and guided tissue regeneration on maxillary osteotomy healing in rabbits

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Kraig StetzerMark P Mooney

Abstract

The development of fibrous nonunions after orthognathic surgery is thought to result from an interaction of biomechanical stress and the differential and more rapid migration of fibroblasts (compared with osteoblasts) into the wound site during healing. The present study was designed to test this hypothesis through the manipulation of guided tissue regeneration and osteotomy fixation techniques in an experimental rabbit model. Bilateral critical size (4 mm) defects (n = 24) were produced in the maxillae of 12 adult New Zealand white rabbits. The maxillary segments were rigidly or nonrigidly fixed using bone microplates and screws or osteosynthetic wires. The defects were then covered with a resorbable collagen membrane or left uncovered. The rabbits were followed for 4 weeks with the use of serial dorsoventral and lateral oblique cephalographs, and the maxillae were then harvested for histologic analyses. Radiographic and histomorphometric analyses revealed that rigidly fixed defects, covered with membrane, showed the most rapid and organized new bone formation. The rigidly fixed defects with the membrane averaged approximately 40% more new bone in the osteotomy site compared with the rigidly fixed defects with no membrane. Non...Continue Reading

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Citations

Aug 24, 2017·European Journal of Oral Sciences·Ibrahim ElgaliPeter Thomsen
Oct 1, 2017·The Journal of Craniofacial Surgery·Patricia Stoor, Satu Apajalahti
Dec 31, 2019·BioMed Research International·Perry RazHaim Tal
May 21, 2010·Journal of the Royal Society, Interface·Yuelian LiuKlaas de Groot
Dec 8, 2011·Clinical Implant Dentistry and Related Research·Florian G DraenertWilfried Wagner
Sep 15, 2017·Tissue Engineering. Part a·Sofia G Caridade, João F Mano
Jul 29, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Emily L DurhamJames Cray
Mar 8, 2016·International Journal of Molecular Sciences·Haiping LuGang Wu

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