PMID: 2498926Jan 1, 1989Paper

Effects of fixed ratio size and dose on phencyclidine self-administration by rats

Psychopharmacology
K L MarquisJ E Moreton

Abstract

Female Sprague-Dawley rats were trained to self-administer phencyclidine (PCP; 0.125, 0.25, or 0.5 mg/kg/injection) on a fixed ratio (FR) schedule of reinforcement under limited access conditions (3 h). Initial training began with cocaine, which was later replaced with ketamine and then one of the three unit doses of PCP. Baseline rates of injection were determined at FR 10. The size of the ratio was then incremented geometrically every fifth daily session. Increasing the ratio resulted in a decrease in the number of injections per session. Furthermore, this decrease was greater for the 0.25 mg/kg dose than for the 0.5 mg/kg unit dose. The self-administration of the 0.125 mg/kg dose was variable and rapidly extinguished upon the increase in fixed ratio. The results indicate that PCP is self-administered by rats under the conditions imposed in this study. Furthermore, the relative reinforcing efficacy of the different unit doses of PCP could be discriminated using this type of response cost procedure.

References

Jun 1, 1987·Pharmacology, Biochemistry, and Behavior·K L Marquis, J E Moreton
Jan 1, 1984·Psychopharmacology·R J CollinsR R Russell
Jan 1, 1984·Psychopharmacology·S E LukasR M Wurster
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May 1, 1964·Journal of Applied Physiology·J R WEEKS, J D DAVIS

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Citations

Jun 4, 2005·Pharmacology, Biochemistry, and Behavior·Zuzana JustinovaGianluigi Tanda
Jan 8, 2008·Psychological Medicine·C J A MorganH V Curran
Jan 14, 2016·Psychopharmacology·Adam L HalberstadtSusan B Powell
Jul 23, 2011·Addiction·Celia J A MorganUNKNOWN Independent Scientific Committee on Drugs
Sep 1, 1993·Drug and Alcohol Dependence·W K BickelS T Higgins
Oct 16, 2014·Drug Development Research·Todd M HillhouseS Stevens Negus
Nov 3, 2010·Neuroscience and Biobehavioral Reviews·Eoin C O'ConnorAndy N Mead
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·G WingerJ H Woods
Oct 13, 1998·Journal of the Experimental Analysis of Behavior·M J Macenski, R A Meisch
Mar 1, 1991·Journal of the Experimental Analysis of Behavior·W K BickelS T Higgins
Jan 15, 2021·Pharmacology, Biochemistry, and Behavior·Fernando B de MouraStephen J Kohut

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