Effects of FK409, a nitric oxide donor, on renal responses to renal nerve stimulation in anesthetized dogs

European Journal of Pharmacology
K TadanoY Matsumura

Abstract

We examined the effects of (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409), a nitric oxide (NO) donor, on renal actions and norepinephrine overflow induced by renal nerve stimulation in anesthetized dogs, with or without N(G)-nitro-L-arginine (NOARG), a NO synthase inhibitor. Renal nerve stimulation at a low frequency (0.5-2.0 Hz) produced significant decreases in urine flow and urinary excretion of Na+ and increases in norepinephrine secretion rate. Renal nerve stimulation at a high frequency (2.5-5.0 Hz) which diminishes renal hemodynamics, elicited more marked decreases in urine formation and increases in norepinephrine secretion rate. Intrarenal arterial infusion of FK409 (0.25 microg/kg/min) failed to alter renal actions and increases in norepinephrine secretion rate in response to both low- and high frequency renal nerve stimulation. When NOARG (40 microg/kg/min) was administrated intrarenally, low-frequency renal nerve stimulation caused a potent antidiuresis and renal vasoconstriction. The renal nerve stimulation-induced increase in norepinephrine secretion rate was markedly enhanced by NOARG infusion. Simultaneous infusion of FK409 markedly attenuated the NOARG-induced enhancement of renal actions a...Continue Reading

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Citations

Dec 4, 2003·European Journal of Pharmacology·Toshihide FujiiYasuo Matsumura
Jun 13, 2002·Clinical and Experimental Pharmacology & Physiology·Hamzeh H ElayanMichael G Ziegler
Sep 22, 2009·European Journal of Pharmacology·Shuhei KobuchiYasuo Matsumura
Mar 20, 2012·European Journal of Pharmacology·Ryosuke TanakaYasuo Matsumura
Mar 22, 2008·Journal of Cardiovascular Pharmacology·Takahiro SugiuraYasuo Matsumura
Oct 5, 2010·Cardiovascular Research·Mark GilchristNigel Benjamin

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