Effects of flagellin on the functions of follicle-associated epithelium.

The Journal of Infectious Diseases
Sophie M ChabotM R Neutra

Abstract

Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicle-associated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase-dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.

References

Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A T GewirtzJ L Madara
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·F SierroJ C Sirard
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T D Eaves-PylesR B Pyles
Dec 26, 2003·The American Journal of Pathology·Andreas GebertKarl-Heinz Wendlandt
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arnaud DidierlaurentJean-Claude Sirard
Aug 11, 2004·The Journal of Biological Chemistry·Jean-Christophe BambouValérie Gaboriau-Routhiau
Oct 19, 2004·Trends in Microbiology·Hugo Cruz RamosJean-Claude Sirard
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sophie ChabotMarian R Neutra

❮ Previous
Next ❯

Citations

Nov 13, 2009·Scandinavian Journal of Immunology·P Brandtzaeg
Sep 29, 2009·Molecular Immunology·Siobhan B Cashman, John G Morgan
Oct 19, 2017·Frontiers in Immunology·Clément Da SilvaHugues Lelouard
Feb 28, 2020·Nature Reviews. Gastroenterology & Hepatology·Juan F Burgueño, Maria T Abreu
Nov 20, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Igor M Belyakov, Jeffrey D Ahlers
Aug 28, 2019·Current Immunology Reviews·Pamela A Kozlowski, Anna Aldovini
Jul 18, 2019·Frontiers in Immunology·Andrea Dillon, David D Lo
Oct 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing WangDavid D Lo
Aug 6, 2019·Frontiers in Immunology·Cynthia Calzas, Christophe Chevalier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.